Abstract
The goal of this chapter is to highlight the powerful influence that our experience can exert on the brain during development. We begin by providing an overview of brain development, an ongoing process that begins shortly after conception, and ends in early adulthood. We will then discuss how and when experience influences the developing brain. We provide several examples in different domains – sensory, language, memory, and social and emotional development – illustrating the astonishing plastic ability that the brain exhibits throughout development. These examples will provide two critical bits of information: first, a normative experience during the first years of life is essential for brain anatomy and brain function to develop normally; second, each neural circuit is differentially sensitive (malleable or vulnerable) to experience as it matures. Therefore the same experience will not have the same impact during infancy, childhood, or adolescence. In the same way, therapeutics and interventions aimed to alleviate deleterious environmental effects have to be applied during specific times of development, depending on the neural circuit and the function targeted in order to be optimally effective. Overall, we hope this chapter will promote the importance of developmental neuroscience research to better understand the needs of our children and their vulnerabilities, and in so doing to improve child policies and intervention programs.
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Adlam, A., Vargha-Khadem, F., Mishkin, M., & De Haan, M. (2005). Deferred imitation of action sequences in developmental amnesia. Journal of Cognitive Neuroscience, 17, 240–248.
Altman, J., & Das, G. D. (1965). Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats. The Journal of Comparative Neurology, 124(3), 319–335.
Bachevalier, J., & Vargha-Khadem, F. (2005). The primate hippocampus: Ontogeny, early insult, and memory. Current Opinion in Neurobiology, 15, 168–174.
Baddeley, A., Vargha-Khadem, F., & Mishkin, M. (2001). Preserved recognition in case of developmental amnesia: Implications for the acquisition of semantic memory? Journal of Cognitive Neuroscience, 13, 357–369.
Badre, D., & Wagner, A. D. (2007). Left ventrolateral prefrontal cortex and the cognitive control of memory. Neuropsychologia, 45(13), 2883–2901.
Banta Lavenex, P., Amaral, D. G., & Lavenex, P. (2006). Hippocampal lesion prevents spatial relational learning in adult macaque monkeys. Journal of Neuroscience, 26(17), 4546–4558.
Benes, F., Turtle, M., Khan, Y., & Farol, P. (1994). Myelination of a key relay zone in the hippocampal formation occurs in the human brain during childhood, adolescence, and adulthood. Archives of General Psychiatry, 51, 477–484.
Black, J. E., Jones, T. A., Nelson, C. A., & Greenough, W. T. (1998). Neuronal plasticity and the developing brain. In N. E. Alessi, J. T. Coyle, S. I. Harrison, & S. Eth (Eds.), Handbook of child and adolescent psychiatry (pp. 31–53). New York: Wiley.
Bos, K. J., Fox, N., Zeanah, C. H., & Nelson, C. A. (2009). Effects of early psychosocial deprivation on the development of memory and executive function. Frontiers in Behavioral Neuroscience, 3, 1–7.
Bourgeois, J. P., Jastreboff, P. J., & Rakic, P. (1989). Synaptogenesis in visual cortex of normal and preterm monkeys: Evidence for intrinsic regulation of synaptic overproduction. Proceedings of the National Academy of Sciences of the United States of America, 86(11), 4297–4301.
Bronner-Fraser, M., & Hatten, M. B. (2003). Neurogenesis and migration. In L. R. Squire, F. E. Bloom, S. K. McConnell, J. L. Roberts, N. C. Spitzer, & M. J. Zigmond (Eds.), Fundamental neuroscience (2nd ed., pp. 391–416). New York: Academic.
Brown, M., Keynes, R., & Lumsden, A. (2001). The developing brain. Oxford, England: Oxford University Press.
Chance, J. E., Turner, A. L., & Goldstein, A. G. (1982). Development of differential recognition for own- and other-race faces. Journal of Psychology, 112, 29–37.
Chechik, G., Meilijson, I., & Ruppin, E. (1999). Neuronal regulation: A mechanism for synaptic pruning during brain maturation. Neural Computation, 11(8), 2061–2080.
Cheng, E. F., & Merzenich, M. M. (2003). Environmental noise retards auditory cortical development. Science, 300, 498–502.
Curtis, W. J. & Nelson, C. A. (2003). Toward building a better brain: Neurobehavioral outcomes, mechanisms, and processes of environmental enrichment. In Luthar, S. S. (Ed.), Resilience and vulnerability: Adaptation in the context of childhood adversities. New York: Cambridge University Press, pp. 463–488.
Dehaene, S., Dupoux, E., Mehler, J., Cohen, L., Paulesu, E., Perani, D., et al. (1997). Anatomical variability in the cortical representation of the first and second language. NeuroReport, 8, 3809–3815.
Durston, S., Hulshoff Pol, H. E., Casey, B. J., Giedd, J. N., Buitelaar, J. K., & van Engeland, H. (2001). Anatomical MRI of the developing human brain: What have we learned? Journal of the American Academy of Child and Adolescent Psychiatry, 40(9), 1012–1020.
Eriksson, P. S., Perfilieva, E., Bjork-Eriksson, T., Alborn, A.-M., Nordborg, C., Peterson, D. A., & Gage, F. H. (1998). Neurogenesis in the adult human hippocampus. Nature Medicine, 4(11), 1313–1317.
Fagan, J. F. (1972). Infants’ recognition memory for faces. Journal of Experimental Child Psychology, 14(3), 453–476.
Fine, I., Smallman, H. S., Doyle, P., & MacLeod, D. I. A. (2002). Visual function before and after the removal of bilateral congenital cataracts in adulthood. Vision Research, 42(2), 191–210.
Fox, S. E., Levitt, P., & Nelson, C. A. (2010). How the timing and quality of early experiences influence the development of brain architecture. Child Development, 81(1), 28–40.
Gadian, D. G., Aicardi, J., Watkins, K. E., Porter, D. A., Mishkin, M., & Vargha-Khadem, F. (2000). Developmental amnesia associated with early hypoxic-ischaemic injury. Brain, 123(3), 499–507.
Giedd, J. N., Snell, J. W., Lange, N., Rajapakse, J. C., Casey, B. J., Kozuch, P. L., Vaituzis, A. C., et al. (1996a). Quantitative magnetic resonance imaging of human brain development: Ages 4–18. Cerebral Cortex, 6(4), 551–560.
Giedd, J. N., Vaituzis, A. C., Hamburger, S. D., Lange, N., Rajapakse, J. C., Kaysen, D., Vauss, Y. C., et al. (1996b). Quantitative MRI of the temporal lobe, amygdala, and hippocampus in normal human development: Ages 4–18 years. The Journal of Comparative Neurology, 366(2), 223–230.
Gould, E. (2007). How widespread is adult neurogenesis in mammals? Nature Reviews. Neuroscience, 8, 481–488.
Greenough, W. T., Black, J. E., & Wallace, C. S. (1987). Experience and brain development. Child Development, 58(3), 539–559.
Greenough, W. T., Wallace, C. S., Alcantra, A. A., Anderson, B. J., Hawrylak, N., Sirevaag, A. M., Weiler, I. J., et al. (1993). Development of the brain: Experience affects the structure of neurons, glia, and blood vessels. In N. J. Anastasiow & S. Harel (Eds.), At-risk infants: Interventions, families, and research (pp. 173–185). Baltimore: Paul H. Brookes.
Gunnar, M. (2001). Effects of early deprivation: Findings from orphanage-reared children. In C. A. Nelson & M. Luciana (Eds.), Handbook of Cognitive Neuroscience (pp. 617–629). Cambridge: MIT Press.
Huttenlocher, P. R. (1979). Synaptic and dendritic development and mental defect. In N. Buchwald & M. Brazier (Eds.), Brain mechanisms in mental retardation (pp. 123–140). New York: Academic.
Huttenlocher, P. R. (1994). Synaptogenesis, synapse elimination, and neural plasticity in human cerebral cortex. In C. A. Nelson (Ed.), Minnesota symposia on child psychology (Cognition, perception, and language, Vol. 27, pp. 35–54). Hilsdale: Lawrence Erlbaum.
Huttenlocher, P. R. (2002). Neural plasticity: The effects of environment on the development of the cerebral cortex. Cambridge, MA: Harvard University Press.
Huttenlocher, P. R., & Dabholkar, A. S. (1997). Regional differences in synaptogenesis in human cerebral cortex. The Journal of Comparative Neurology, 387(2), 167–178.
Huttenlocher, P. R., & de Courten, C. (1987). The development of synapses in striate cortex of man. Human Neurobiology, 6, 1–9.
Isaacs, E., Vargha-Khadem, F., Watkins, K., Lucas, A., Mishkin, M., & Gadian, D. (2003). Developmental amnesia and its relationship to degree of hippocampal atrophy. Proceedings of the National Academy of Sciences of the United States of America, 100, 13060–13063.
Jabès, A., Lavenex, P. B., Amaral, D. G., & Lavenex, P. (2010). Quantitative analysis of postnatal neurogenesis and neuron number in the macaque monkey dentate gyrus. European Journal of Neuroscience, 31(2), 273–285.
Jabès, A., Banta Lavenex, P., Amaral, D. G., & Lavenex, P. (2011). Postnatal development of the hippocampal formation: A stereological study in macaque monkeys. The Journal of Comparative Neurology, 519(6), 1051–1070.
Jernigan, T. L., Trauner, D. A., Hesselink, J. R., & Tallal, P. A. (1991). Maturation of the human cerebrum observed in vivo during adolescence. Brain, 114, 2037–2049.
Johnson, J. S., & Newport, E. L. (1989). Critical period effects in second language learning: The influence of maturational state on the acquisition of English as a second language. Cognitive Psychology, 21, 60–99.
Kandel, E. R., Schwartz, J. H., & Jessel, T. M. (1992). Principles of neural science (3rd ed.). New York: McGraw-Hill.
Keith, A. (1948). Human embryology and morphology. London: Edward Arnold.
Kempermann, G., Kuhn, G., & Gage, F. H. (1997). More hippocampal neurons in adult mice living in an enriched environment. Nature, 386, 493–495.
Kempermann, G., Kuhn, H. G., & Gage, F. H. (1998). Experienced-induced neurogenesis in the senescent dentate gyrus. Journal of Neuroscience, 18, 3206–3212.
King, J. A., Trinkler, I., Hartley, T., Vargha-Khadem, F., & Burgess, N. (2004). The hippocampal role in spatial memory and the familiarity–recollection distinction: A case study. Neuropsychology, 18(3), 405–417.
Knudsen, E. I. (2003). Early experience and critical periods. In L. R. Squire, F. E. Bloom, S. K. McConnell, J. L. Roberts, N. C. Spitzer, & M. J. Zigmond (Eds.), Fundamental neuroscience (2nd ed., pp. 555–573). New York: Academic.
Koenderink, M. J., & Uylings, H. B. (1995). Postnatal maturation of layer V pyramidal neurons in the human prefrontal cortex. A quantitative Golgi analysis. Brain Research, 678, 233–243.
Kostovic, I. (1991). Structural and histochemical reorganization of the human prefrontal cortex during perinatal and postnatal life. Progress in Brain Research, 85, 223–240.
Kral, A., & Eggermont, J. J. (2007). What’s to lose and what’s to learn: Development under auditory deprivation, cochlear implants and limits of cortical plasticity. Brain Research Reviews, 56(1), 259–269.
Kriegstein, A. R., & Gotz, M. (2003). Radial glia diversity: A matter of cell fate. Glia, 43(1), 37–43.
Kuhl, P. K. (2010). Brain mechanisms in early language acquisition. Neuron, 67(5), 713–727.
Kuhl, P. K., Tsao, F. M., & Liu, H. M. (2003). Foreign-language experience in infancy: Effects of short-term exposure and social interaction on phonetic learning. Proceedings of the National Academy of Sciences, 100, 9096–9101.
Lavenex, P., Banta Lavenex, P., & Amaral, D. G. (2007). Spatial relational learning persists following neonatal hippocampal lesions in macaque monkeys. Nature Neuroscience, 10(2), 234–239.
Le Bé, J.-V., & Markram, H. (2006). Spontaneous and evoked synaptic rewiring in the neonatal neocortex. Proceedings of the National Academy of Sciences of the United States of America, 103(35), 13214–13219.
Levitt, P. (2003). Structural and functional maturation of the developing primate brain. The Journal of Pediatrics, 143(4 Suppl.), 35–45.
Lie, D. C., Song, H., Colamarino, S. A., Ming, G.-L., & Gage, F. H. (2004). Neurogenesis in the adult brain: New strategies for central nervous system diseases. Annual Review of Pharmacology and Toxicology, 44, 399–421.
Lumsden, A., & Kintner, C. (2003). Neural induction and pattern formation. In L. R. Squire, F. E. Bloom, S. K. McConnell, J. L. Roberts, N. C. Spitzer, & M. J. Zigmond (Eds.), Fundamental neuroscience (2nd ed., pp. 363–390). New York: Academic.
Marin-Padilla, M. (1978). Dual origin of the mammalian neocortex and evolution of the cortical plate. Anatomy and Embryology, 152, 109–126.
Maurer, D., Lewis, T. L., Brent, H. P., & Levin, A. V. (1999). Rapid improvement in the acuity of infants after visual input. Science, 286(5437), 108–110.
Mayberry, R. I., Lock, E., & Kazmi, H. (2002). Linguistic ability and early language exposure. Nature, 417, 38.
Menon, V., Boyett-Anderson, J. M., & Reiss, A. L. (2005). Maturation of medial temporal lobe response and connectivity during memory encoding. Brain Research. Cognitive Brain Research, 25(1), 379–385.
Mohindra, I., Jacobson, S. G., & Held, R. (1983). Binocular visual form deprivation in human infants. Documenta Ophthalmologica, 55, 237–249.
Molliver, M. E., Kostovi, I., & van der Loos, H. (1973). The development of synapses in cerebral cortex of the human fetus. Brain Research, 50, 403–407.
Moulson, M. C., Fox, N. A., Zeanah, C. H., & Nelson, C. A. (2009). Early adverse experiences and the neurobiology of facial emotion processing. Developmental Psychology, 45(1), 17–30.
Mrzljak, L., Uylings, H. B. M., Kostovic, I., & Van Eden, C. G. (1988). Prenatal development of neurons in the human prefrontal cortex: I. A qualitative Golgi study. The Journal of Comparative Neurology, 271, 355–386.
Nadarajah, B., & Parnavelas, J. G. (2002). Models of neuronal migration in the developing cerebral cortex. Nature Reviews. Neuroscience, 3, 423–432.
Nelson, C. A. (2001). The development and neural bases of face recognition. Infant and Child Development, 10, 3–18.
Nelson, C. A. (2003). The development of face recognition reflects an experience-expectant and activity-dependent process. In O. Pascalis & A. Slater (Eds.), The development of face processing in infancy and early childhood: Current perspectives (pp. 79–97). Hauppauge: Nova.
Nelson, C. A., & Bloom, F. E. (1997). Child development and neuroscience. Child Development, 68(5), 970–987.
Nelson, C. A., Parker, S. W., Guthrie, D., & The BEIP Core Group. (2006a). The discrimination of facial expressions by typically developing infants and toddlers and those experiencing early institutional care. Infant Behavior & Development, 29(2), 210–219.
Nelson, C. A., Thomas, K. M., & de Haan, M. (2006b). Neural bases of cognitive development. In W. Damon, R. Lerner, D. Kuhn, & R. Siegler (Eds.), Handbook of child psychology: Cognition, perception, and language (6th ed., pp. 3–57). Hoboken: Wiley.
Nelson, C. A., Zeanah, C., Fox, N., Marshall, P., Smyke, A., & Guthrie, D. (2007). Cognitive recovery in socially deprived young children: The Bucharest Early Intervention Project. Science, 318, 1937–1940.
Newman, A. J., Bavelier, D., Corina, D., Jezzard, P., & Neville, H. J. (2002). A critical period for right hemisphere recruitment in American sign language processing. Nature Neuroscience, 5, 76–80.
Ofen, N., Kao, Y. C., Sokol-Hessner, P., Kim, H., Whitfield-Gabrieli, S., & Gabrieli, J. D. (2007). Development of the declarative memory system in the human brain. Nature Neuroscience, 10(9), 1198–1205.
Oppenheim, R. W., & Johnson, J. (2003). Programmed cell death and neurotrophic factors. In L. R. Squire, F. E. Bloom, S. K. McConnell, J. L. Roberts, N. C. Spitzer, & M. J. Zigmond (Eds.), Fundamental neuroscience (2nd ed., pp. 499–532). New York: Academic.
O’Toole, A. J., Deffenbacher, K. A., Valentin, D., & Abdi, H. (1994). Structural aspects of face recognition and the other-race effect. Memory and Cognition, 22, 208–224.
Pascalis, O., & Bachevalier, J. (1998). Face recognition in primates: A cross-species study. Behavioural Processes, 43, 87–96.
Pascalis, O., de Haan, M., & Nelson, C. A. (2002). Is face processing species-specific during the first year of life? Science, 296, 1321–1323.
Paus, T., Zijdenbos, A., Worsley, K., Collins, D. L., Blumenthal, J., Giedd, J. N., Rapoport, J. L., et al. (1999). Structural maturation of neural pathways in children and adolescents: In vivo study. Science, 283(5409), 1908–1911.
Perani, D., Paulesu, E., Sebastian Galles, N., Dupoux, E., Dehaene, S., Bettinardi, V., et al. (1998). The bilingual brain. Proficiency and age of acquisition of the second language. Brain, 121, 1841–1852.
Petitto, L. A., Zatorre, R. J., Gauna, K., Nikelski, E. J., Dostie, D., & Evans, A. C. (2000). Speech-like cerebral activity in profoundly deaf people processing signed languages: Implications for the neural basis of human language. Proceedings of the National Academy of Sciences, 97(25), 13961–13966.
Pollak, S., Nelson, C., Schlaak, M., Roeber, B., Wewerka, S., Wiik, K., Frenn, K., et al. (2010). Neurodevelopmental effects of early deprivation in post-institutionalized children. Child Development, 81(1), 224–236.
Pravosudov, V. V., Lavenex, P., & Omanska, A. (2005). Nutritional deficits during early development affect hippocampal structure and spatial memory later in life. Behavioral Neuroscience, 119(5), 1368–1374.
Rakic, P., & Nowakowski, R. S. (1981). The time of origin of neurons in the hippocampal region of the rhesus monkey. The Journal of Comparative Neurology, 196(1), 99–128.
Richmond, J., & Nelson, C. A. (2008). Mechanisms of change: A cognitive neuroscience approach to declarative memory development. In C. A. Nelson & M. Luciana (Eds.), Handbook of developmental cognitive neuroscience (2nd ed.). Cambridge, MA: Bradford.
Saffran, J. R, Werker, J. F., & Werner, L. A. (2006). Cognition, perception, and language. In R. M. Lerner & W. Damon (Eds.), Handbook of child psychology (6th ed., Vol. 2, pp. 58–108). Hoboken, NJ: Wiley.
Sanes, D., & Bao, S. (2009). Tuning up the developing auditory CNS. Current Opinion in Neurobiology, 19(2), 188–199.
Sanes, D. H., Reh, T. A., & Harris, W. A. (2011). Chapter 5. Axon growth and guidance. In Development of the nervous system (3rd ed., pp. 105–142). Oxford, UK: Academic.
Scott, L., & Nelson, C. A. (2004). The developmental neurobiology of face processing. In B. J. Casey (Ed.), Developmental psychobiology (Review of psychiatry series, Vol. 23, pp. 29–68). Arlington: American Psychiatric Publishing.
Sharma, A., Dorman, M. F., & Spahr, A. J. (2002). A sensitive period for the development of the central auditory system in children with cochlear implants: Implications for age of implantation. Ear and Hearing, 23(6), 532–539.
Sharma, A., Dorman, M. F., & Kral, A. (2005). The influence of a sensitive period on central auditory development in children with unilateral and bilateral cochlear implants. Hearing Research, 203(1–2), 134–143.
Sidman, R., & Rakic, P. (1982). Development of the human central nervous system. In W. Haymaker & R. D. Adams (Eds.), Histology and histopathology of the nervous system (pp. 3–145). Springfield: Charles C Thomas.
Sluzenski, J., Newcombe, N. S., & Kovacs, S. L. (2006). Binding, relational memory, and recall of naturalistic events: A developmental perspective. Journal of Experimental Psychology: Learning, Memory, and Cognition, 32(1), 89–100.
Smyke, A., Koga, S., Johnson, D., Fox, N., Marshall, P., Nelson, C., Zeanah, C., et al. (2007). The caregiving context in institution-reared and family-reared infants and toddlers in Romania. Journal of Child Psychology and Psychiatry, 48(2), 210–218.
Smyke, A. T., Zeanah, C. H., Fox, N. A., Nelson, C. A., & Guthrie, D. (2010). Placement in foster care enhances quality of attachment among young institutionalized children. Child Development, 81(1), 212–223.
Sowell, E. R., Thompson, P. M., Holmes, C. J., Jernigan, T. L., & Toga, A. W. (1999). In vivo evidence for post-adolescent brain maturation in frontal and striatal regions. Nature Neuroscience, 2(10), 859–861.
Squire, L. R., & Zola, S. M. (1996). Structure and function of declarative and nondeclarative memory systems. Proceedings of the National Academy of Sciences of the United States of America, 93(24), 13515–13522.
Tessier-Lavigne, M., & Goodman, C. S. (1996). The molecular biology of axon guidance. Science, 274(5290), 1123–1133.
Turkheimer, E., Haley, A., Waldron, M., Onofrio, B. D., & Gottesman, I. I. (2003). Socioeconomic status modifies heritability of IQ in young children. Psychological Science, 14(6), 623–628.
van Praag, H., Kempermann, G., & Gage, F. H. (2000). Neural consequences of environmental enrichment. Nature Reviews. Neuroscience, 1(3), 191–198.
Vargha-Khadem, F., Gadian, D. G., Watkins, K. E., Connelly, A., VanPaesschen, W., & Mishkin, M. (1997). Differential effects of early hippocampal pathology on episodic and semantic memory. Science, 277(5324), 376–380.
Vargha-Khadem, F., Gadian, D., & Mishkin, M. (2001). Dissociations in cognitive memory: The syndrome of developmental amnesia. Philosophical Transactions of the Royal Society London (Biology), 356, 1435–1440.
Vargha-Khadem, F., Salmond, C. H., Watkins, K. E., Friston, K. J., Gadian, D. G., & Mishkin, M. (2003). Developmental amnesia: Effect of age at injury. Proceedings of the National Academy of Sciences of the United States of America, 100, 10055–10060.
Webb, S. J., Monk, C. S., & Nelson, C. A. (2001). Mechanisms of postnatal neurobiological development: Implications for human development. Developmental Neuropsychology, 19(2), 147–171.
Werner, L., Fay, R. R., & Popper, A. N. (Eds.). (2012). Human auditory development. New York: Springer.
Windsor, J., Benigno, J. P., Wing, C. A., Carroll, P. J., Koga, S. F., Nelson, C. A., Fox, N. A., et al. (2011). Effect of foster care on young children’s language learning. Child Development, 82(4), 1040–1046.
Zeanah, C. H., Nelson, C. A., Fox, N. A., Smyke, A. T., Marshall, P., Parker, S. W., & Koga, S. (2003). Designing research to study the effects of institutionalization on brain and behavioral development: The Bucharest Early Intervention Project. Development and Psychopathology, 15, 885–907.
Zeanah, C. H., Smyke, A. T., Koga, S. F., Carlson, E., & The BEIP Core Group. (2005). Attachment in institutionalized and community children in Romania. Child Development, 76(5), 1015–1028.
Zhang, L. I., Bao, S., & Merzenich, M. M. (2002). Disruption of primary auditory cortex by synchronous auditory inputs during a critical period. Proceedings of the National Academy of Sciences of the United States of America, 99(4), 2309–2314.
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Jabès, A., Nelson, C.A. (2014). Neuroscience and Child Well-Being. In: Ben-Arieh, A., Casas, F., Frønes, I., Korbin, J. (eds) Handbook of Child Well-Being. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9063-8_10
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