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Marine Natural Products Active Against Protozoan Parasites

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Handbook of Marine Natural Products

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Abstract

Protozoa are the causative agents of human diseases which affect more than one billion people and cause more than one million deaths per year, with a particular incidence in developing countries. The major contribution to these dramatic numbers is given by malaria, followed by leishmaniasis and trypanosomiasis (African trypanosomiasis and Chagas’ disease).

In this chapter we have provided an overview of the most significant contributions given by marine natural product chemistry to the field of antiprotozoan drug research. We have selected more than 70 marine secondary metabolites belonging to different chemical classes, which are active (commonly only in vitro data are available) against one or more protozoan strains. When available, details on structure–activity relationship studies and investigation of the mechanisms of action have been provided.

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  1. Dipartimento di Chimica delle Sostanze Naturali, Università di Napoli Federico II, Via Montesano 49, Naples, I-80131, Italy

    Ernesto Fattorusso & Orazio Taglialatela-Scafati

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  1. Ernesto Fattorusso
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  2. Orazio Taglialatela-Scafati
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Corresponding authors

Correspondence to Ernesto Fattorusso or Orazio Taglialatela-Scafati .

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Editors and Affiliations

  1. Facoltà di Farmacia, Dipto. Chimica delle Sostanze Naturali, Università di Napoli, Via Domenico Montesano 49, Napoli, 80131, Italy

    Ernesto Fattorusso

  2. Scripps Inst. Oceanography, University of California, San Diego, Gilman Drive 9500, La Jolla, 92093-0213, California, USA

    William H. Gerwick

  3. Facoltà di Farmacia, Dipto. Chimica delle Sostanze Naturali, Università di Napoli, Via Domenico Montesano 49, Napoli, 80131, Italy

    Orazio Taglialatela-Scafati

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© 2012 Springer Science+Business Media B.V.

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Fattorusso, E., Taglialatela-Scafati, O. (2012). Marine Natural Products Active Against Protozoan Parasites. In: Fattorusso, E., Gerwick, W., Taglialatela-Scafati, O. (eds) Handbook of Marine Natural Products. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-3834-0_21

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