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Addiction to Caffeine and Other Xanthines

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Textbook of Addiction Treatment: International Perspectives

Abstract

Xanthine (3,7-dihydro-purine-2,6-dione) is a purine base that can naturally be found in human body tissues and fluids as well as in plants and other organisms. Methylated xanthines (methylxanthines) are phosphodiesterase inhibitors and adenosine receptor antagonists. Methylxanthines have thus different effects: reduce inflammation and immunity, reduce sleepiness and increase alertness, but also stimulate the heart rate and contraction and dilate the bronchi. The most well-known methylxanthines are caffeine, methylbromine, and theophylline. Coffee and caffeine withdrawal symptoms exist and are often not recognized, especially in treatment settings, where caffeine withdrawal can be confounded with other symptoms. Caffeine intoxication and withdrawal are recognized clinical entities, but caffeine dependence is currently not. Caffeine withdrawal occurs in half of regular coffee drinkers, even at moderate caffeine intake. The most common symptoms are headache, fatigue, and difficulty to concentrate. Health professionals and patients should be better informed about these symptoms and the risk of occurrence of caffeine withdrawal. There is little research of treatments for clinical problems associated with xanthine use or abuse.

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Authors and Affiliations

  1. Unit for Dependencies, Division for Primary Care, Department for Community Medicine, Primary Care and Emergencies, Geneva University Hospitals, Geneva, Switzerland

    Thierry Favrod-Coune & Barbara Broers

Authors
  1. Thierry Favrod-Coune
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  2. Barbara Broers
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Corresponding author

Correspondence to Thierry Favrod-Coune .

Editor information

Editors and Affiliations

  1. Department of Psychiatry, Alberta Gambling Research Institute University of Calgary, Calgary, Alberta, Canada

    Nady el-Guebaly

  2. Faculty of Brain Sciences UCL Division of Psychiatry, University College London, London, United Kingdom

    Giuseppe Carrà

  3. Division of Alcoholism & Drug Abuse, New York University School of Medicine, New York, New York, USA

    Marc Galanter

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Favrod-Coune, T., Broers, B. (2015). Addiction to Caffeine and Other Xanthines. In: el-Guebaly, N., Carrà, G., Galanter, M. (eds) Textbook of Addiction Treatment: International Perspectives. Springer, Milano. https://doi.org/10.1007/978-88-470-5322-9_18

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  • DOI: https://doi.org/10.1007/978-88-470-5322-9_18

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  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-5321-2

  • Online ISBN: 978-88-470-5322-9

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