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Magnesium, Vitamins and Herbal Preparations

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Handbook of Headache

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Abstract

Headache patients frequently seek alternatives to traditional acute and preventative treatments, given the side effects often associated with conventional medications. In this chapter, the available evidence for the use of magnesium, coenzyme Q10 (CoQ10), riboflavin, butterbur, feverfew, and alpha lipoic acid in migraine prevention are reviewed. Areas of ongoing research, particularly in pharmacogenetics, are also discussed. Although further research with large-scale randomized controlled trials (RCTs) is necessary to better clarify the efficacy of these vitamins, supplements, and herbal preparations, we recommend the consideration of oral magnesium supplementation in migraineurs in whom there is clinical suspicion of magnesium deficiency, given its safety and tolerability. Butterbur is also recommended for migraine prophylaxis given the positive results from two randomized controlled trials. Though the clinical efficacy data for feverfew, CoQ10, riboflavin, and alpha lipoic acid are equivocal, these substances may also be considered in patients who express an interest in alternative treatments.

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Authors and Affiliations

  1. New York Headache Center, 30 East 76 Street, New York, NY, 10021, USA

    Dr. Alexander Mauskop MD, FAAN

  2. Department of Clinical Neurosciences, Centre for Clinical Neurosciences and Neurological Research, St Vincent’s Hospital, Melbourne, Australia

    Dr. Christina Sun-Edelstein

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  1. Dr. Alexander Mauskop MD, FAAN
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  2. Dr. Christina Sun-Edelstein
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Correspondence to Alexander Mauskop MD, FAAN .

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Editors and Affiliations

  1. Department of Medical and Molecular Sciences, School of Health Sciences, Sapienza University of Rome, Rome, Italy

    Paolo Martelletti

  2. Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway

    Timothy J. Steiner

  3. Department of Neuroscience, Faculty of Medicine, Imperial College London, London, UK

    Timothy J. Steiner

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Mauskop, A., Sun-Edelstein, C. (2011). Magnesium, Vitamins and Herbal Preparations. In: Martelletti, P., Steiner, T.J. (eds) Handbook of Headache. Springer, Milano. https://doi.org/10.1007/978-88-470-1700-9_53

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  • DOI: https://doi.org/10.1007/978-88-470-1700-9_53

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