Skip to main content
SpringerLink
Log in

Managing Headache in Older People

  • Reference work entry
Handbook of Headache

  • 1168 Accesses

Abstract

Adults aged 20–50 years are the most likely headache sufferers but elderly individuals are affected too. In the elderly, as the prevalence of primary headache disorders decreases, the prevalence of secondary headaches increases, but primary headaches remain the main forms also in this age group. Scientific evidence referring to non-pharmacological and pharmacological treatment of headaches in the elderly is poor. So far, most of the available clinical trials excluded old subjects. When treating headache in the elderly, particular caution should be adopted in deciding for acute attack treatment or prevention since the elderly often present comorbid diseases, take polytherapy, and are at increased risk of adverse effects. For this reason, selection of available medications should be made at the individual level considering the above reported factors. Simplification of the drug regimens and downward of dosing are often the most adequate measures.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 279.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • American Geriatrics Society Panel on the Pharmacological Management of Persistent Pain in Older Persons (2009) Pharmacological management of persistent pain in older persons. J Am Geriatr Soc 57:1331–1346

    Google Scholar 

  • Arroyo S, Kramer G (2001) Treating epilepsy in the elderly. Drug Saf 24:991–1015

    PubMed  CAS  Google Scholar 

  • Aw TJ, Haas SJ, Liew D, Krum H (2005) Meta-analysis of cyclooxygenase-2 inhibitors and their effects on blood pressure. Arch Intern Med 165:490–496

    PubMed  CAS  Google Scholar 

  • Bender WI (1995) ACE inhibitors for prophylaxis of migraine headaches. Headache 35:470–471

    PubMed  CAS  Google Scholar 

  • Bigal ME, Liberman JN, Lipton RB (2006) Age-dependent prevalence and clinical features of migraine. Neurology 67:246–251

    PubMed  Google Scholar 

  • Biondi DM, Saper JR (2000) Geriatric headache. How to make the diagnosis and manage the pain. Geriatrics 55:40–50

    PubMed  CAS  Google Scholar 

  • Boers M, Tangelder MJ, van Ingen H, Fort JG, Goldstein JL (2007) The rate of NSAID-induced endoscopic ulcers increases linearly but not exponentially with age: a pooled analysis of 12 randomised trials. Ann Rheum Dis 66:417–418

    PubMed  Google Scholar 

  • Boureau F, Kappos L, Schoenen J, Esperanca P, Ashford E (2000) A clinical comparison of sumatriptan nasal spray and dihydroergotamine nasal spray in the acute treatment of migraine. Int J Clin Pract 54:281–286

    PubMed  CAS  Google Scholar 

  • Brennum J, Kjeldsen M, Olesen J (1992) The 5-HT1-like agonist sumatriptan has a significant effect in chronic tension-type headache. Cephalalgia 12:375–379

    PubMed  CAS  Google Scholar 

  • Brodie MJ, Kwan P (2005) Epilepsy in elderly people. BMJ 331:1317–1322

    PubMed  Google Scholar 

  • Burris JE (2004) Pharmacologic approaches to geriatric pain management. Arch Phys Med Rehabil 85 (Suppl 3):S45–S49

    PubMed  Google Scholar 

  • Castillo J, Munõz P, Guitera V, Pascual J (1999) Epidemiology of chronic daily headache in the general population. Headache 38:497–506

    Google Scholar 

  • Charles JA, Jotkowitz S, Byrd LH (2006) Prevention of migraine with olmesartan in patients with hypertension/prehypertension. Headache 46:503–507

    PubMed  Google Scholar 

  • Christensen S, Riis A, Nørgaard M, Thomsen RW, Sørensen HT (2007) Introduction of newer selective cyclo-oxygenase-2 inhibitors and rates of hospitalization with bleeding and perforated peptic ulcer. Aliment Pharmacol Ther 25:907–912

    PubMed  CAS  Google Scholar 

  • Chronicle E, Mulleners W (2004) Anticonvulsant drugs for migraine prophylaxis. Cochrane Database Syst Rev 3:1–35

    Google Scholar 

  • Chutka DS, Takahashi PY, Hoel RW (2004) Inappropriate medications for elderly patients. Mayo Clin Proc 79:122–139

    PubMed  CAS  Google Scholar 

  • Coleman AL (1999) Glaucoma. Lancet 354:1803–1810

    PubMed  CAS  Google Scholar 

  • Cologno D, Torelli P, Manzoni CG (1998) Migraine with aura. A review of 81 patients at 10–20 years’ follow-up. Cephalalgia 18:690–696

    PubMed  CAS  Google Scholar 

  • de Abajo FJ, Garcia Rodriguez LA (2001) Risk of upper gastrointestinal bleeding and perforation associated with low-dose aspirin as plain and enteric-coated formulations. BMC Clin Pharmacol 1:1

    PubMed  Google Scholar 

  • der Heijden EA Wammes-van, Rahimtoola H, Leufkens HGM, Tijssen CC, Egberts ACG (2006) Risk of ischemic complications related to the intensity of triptan and ergotamine use. Neurology 67:1128–1134

    Google Scholar 

  • Diener HC, Gendolla A, Feuersenger A, Evers S, Straube A, Schumacher H, Davidai G (2009) Telmisartan in migraine prophylaxis: a randomized, placebo-controlled trial. Cephalalgia 29:92–97

    Google Scholar 

  • Dowson A, Ball K, Haworth D (2000) Comparison of a fixed combination of domperidone and paracetamol (domperamol) with sumatriptan 50 mg in moderate to severe migraine: a randomized UK primary care study. Curr Med Res Opin 16:190–197

    PubMed  CAS  Google Scholar 

  • Edmeads J (2000) Headache in the elderly. In: Olesen J, Tfelt-Hansen P, Welch KMA (eds) The headaches, 2nd edn. Lippincott Williams & Wilkins, Philadelphia, pp 947–951

    Google Scholar 

  • Edmeads JG, Wang SJ (2006) Headaches in the elderly. In: Olesen J, Goadsby PJ, Ramadan NM, Tfelt-Hansen P, Welch KMA (eds) The headaches, 3rd edn. Lippincott Williams & Wilkins, Philadelphia, pp 1105–1110

    Google Scholar 

  • Eriksen MK, Thomsen LL, Russell MB (2004) Prognosis of migraine with aura. Cephalalgia 24:18–22

    PubMed  CAS  Google Scholar 

  • Fishbain DA, Cole B, Lewis J, Rosomoff HL, Rosomoff RS (2008) What percentage of chronic nonmalignant pain patients exposed to chronic opioid analgesic therapy develop abuse/addiction and/or aberrant drug-related behaviors? A structured evidence-based review. Pain Med 9:444–459

    PubMed  Google Scholar 

  • Fishman SM, Wilsey B, Mahajan G, Molina P (2002) Methadone reincarnated: novel clinical applications with related concerns. Pain Med 3:339–348

    PubMed  Google Scholar 

  • Geraud G, Compagnon A, Rossi A, Cozam Study Group (2002) Zolmitriptan versus a combination of acetlysalicylic acid and metoclopramide in the acute oral treatment of migraine: a double-blind, randomised, three-attack study. Eur Neurol 47:88–89

    PubMed  CAS  Google Scholar 

  • Gladding PA, Webster MW, Farrell HB, Zeng IS, Park R, Ruijne N (2008) The antiplatelet effect of six non-steroidal anti-inflammatory drugs and their pharmacodynamic interaction with aspirin in healthy volunteers. Am J Cardiol 101:1060–1063

    PubMed  CAS  Google Scholar 

  • Gladstone JP, Eross EJ, Dodick DW (2004) Migraine in special populations. Treatment strategies for children and adolescents, pregnant women, and the elderly. Postgrad Med 115:39–50

    PubMed  Google Scholar 

  • Gloth FM (2001) Pain management in older adults: prevention and treatment. J Am Geriatr Soc 49:188–199

    PubMed  Google Scholar 

  • Goadsby PJ (2005) Calcitonin gene-related peptide antagonists as treatments of migraine and other primary headaches. Drugs 65:2557–2567

    PubMed  CAS  Google Scholar 

  • Goadsby PJ, Sprenger T (2010) Current practice and future directions in the prevention and acute management of migraine. Lancet Neurol 9:285–298

    PubMed  Google Scholar 

  • Goldstein J, Hoffman HD, Armellino JJ, Battikha JP, Hamelsky SW, Couch J, Blumenthal H, Lipton RB (1999) Treatment of severe, disabling migraine attacks in an over-the-counter population of migraine sufferers: results from three randomized placebo-controlled studies of the combination of acetaminophen, aspirin and caffeine. Cephalalgia 19:684–691

    PubMed  CAS  Google Scholar 

  • Goldstein JL, Correa P, Zhao WW, Burr AM, Hubbard RC, Verburg KM, Geis GS (2001) Reduced incidence of gastroduodenal ulcers with celecoxib, a novel cyclooxygenase-2 inhibitor, compared to naproxen in patients with arthritis. Am J Gastroenterol 96:1019–1027

    PubMed  CAS  Google Scholar 

  • Groselj J, Guerrini R, Van Oene J, Lahaye M, Schreiner A, Schwalen S (2005) Experience with topiramate monotherapy in elderly patients with recent onset epilepsy. Acta Neurol Scand 112:144–150

    PubMed  CAS  Google Scholar 

  • Haan J, Hollander J, Ferrari MD (2006) Migraine in the elderly: a review. Cephalalgia 27:97–106

    Google Scholar 

  • Hall GC, Brown MM, Mo J, MacRae KD (2004) Triptans in migraine. The risk of stroke, cardiovascular disease, and death in practice. Neurology 62:563–568

    PubMed  CAS  Google Scholar 

  • Hawkey CJ, Jones RH, Yeomans ND, Scheiman JM, Talley NJ, Goldstein JL, Ahlbom H, Naesdal J (2007) Efficacy of esomeprazole for resolution of symptoms of heartburn and acid regurgitation in continuous users of non-steroidal anti-inflammatory drugs. Aliment Pharmacol Ther 25:813–821

    PubMed  CAS  Google Scholar 

  • Ho TW, Ferrari MD, Dodick DW, Galet V, Kost J, Fan X, Leibensperger H, Froman S, Assaid C, Lines C, Koppen H, Winner PK (2008) Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial. Lancet 372:2115–2123

    PubMed  CAS  Google Scholar 

  • Hur C, Chan AT, Tramontano AC, Gazelle GS (2006) Coxibs versus combination NSAID and PPI therapy for chronic pain: an exploration of the risks, benefits, and costs. Ann Pharmacother 40:1052–1063

    PubMed  CAS  Google Scholar 

  • Inouye SK (2006) Delirium in older persons. N Engl J Med 354:1157–1165

    PubMed  CAS  Google Scholar 

  • Ives TJ, Chelminski PR, Hammett-Stabler CA, Malone RM, Perhac JS, Potisek NM, Shilliday BB, DeWalt DA, Pignone MP (2006) Predictors of opioid misuse in patients with chronic pain: a prospective cohort study. BMC Health Serv Res 6:46

    PubMed  Google Scholar 

  • Izhar M, Alausa T, Folker A, Hung E, Bakris GL (2004) Effects of COX inhibition on blood pressure and kidney function in ACE inhibitor-treated blacks and hispanics. Hypertension 43:573–577

    PubMed  CAS  Google Scholar 

  • Juhlin T, Björkman S, Gunnarsson B, Fyge A, Roth B, Höglund P (2004) Acute administration of diclofenac, but possibly not long term low dose aspirin, causes detrimental renal effects in heart failure patients treated with ACE-inhibitors. Eur J Heart Fail 6:909–916

    PubMed  CAS  Google Scholar 

  • Juhlin T, Björkman S, Höglund P (2005) Cyclooxygenase inhibition causes marked impairment of renal function in elderly subjects treated with diuretics and ACE-inhibitors. Eur J Heart Fail 7:1049–1056

    PubMed  CAS  Google Scholar 

  • Kalso E, Edwards JE, Moore RA, McQuay HJ (2004) Opioids in chronic non-cancer pain: systematic review of efficacy and safety. Pain 112:372–380

    PubMed  CAS  Google Scholar 

  • Kearney PM, Baigent C, Godwin J, Halls H, Emberson JR, Patrono C (2006) Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials. BMJ 332:1302–1308

    PubMed  CAS  Google Scholar 

  • Landy SH, Lobo BL (2005) Migraine treatment throughout the lifecycle. Expert Rev Neurother 5:343–353

    PubMed  CAS  Google Scholar 

  • Limmroth V, Katsarava Z, Fritsche G, Przywara S, Diener H-C (2002) Features of medication overuse headache following overuse of different acute headache drugs. Neurology 59:1011–1014

    PubMed  CAS  Google Scholar 

  • Lipton RB, Stewart WF (1994) The epidemiology of migraine. Eur Neurol 34(suppl 2):6–11

    PubMed  Google Scholar 

  • Lipton RB, Pfeffer D, Newman LC, Solomon S (1993) Headaches in the elderly. J Pain Symptom Manage 8:87–97

    PubMed  CAS  Google Scholar 

  • Lipton RB, Stewart WF, Ryan RE, Saper J, Silberstein S, Sheftell F (1998) Efficacy and safety of acetaminophen, aspirin, and caffeine in alleviating migraine headache pain—three double-blind, randomized, placebo-controlled trials. Arch Neurol 55:210–217

    PubMed  CAS  Google Scholar 

  • Lipton RB, Stewart WF, Diamond S, Diamond ML, Reed M (2001) Prevalence and burden of migraine in the United States: data from the American Migraine Study II. Headache 41:646–657

    PubMed  CAS  Google Scholar 

  • Lisotto C, Mainardi F, Maggioni F, Dainese F, Zanchin G (2004) Headache in the elderly: a clinical study. J Headache Pain 5:36–41

    Google Scholar 

  • Little PJ, Jennings GL, Skews H, Bobik A (1982) Bioavailability of dihydroergotamine in man. Br J Clin Pharmacol 13:785–790

    PubMed  CAS  Google Scholar 

  • Loder E, Biondi D (2005) General principles of migraine management. The changing role of prevention. Headache 45(Suppl 1):S33–S47

    PubMed  Google Scholar 

  • Lyngberg AC, Rasmussen BK, Jørgensen T, Jensen R (2005) Prognosis of migraine and tension-type headache. A population-based follow-up study. Neurology 65:580–585

    PubMed  Google Scholar 

  • MacGregor EA, Wilkinson M, Bancroft K (1993) Domperidone plus paracetamol in the treatment of migraine headache. Cephalalgia 13:124–127

    PubMed  CAS  Google Scholar 

  • Mathew NT, Tiejen GE, Lucker C (1996) Serotonin syndrome complicating migraine pharmacotherapy. Cephalalgia 16:323–327

    PubMed  CAS  Google Scholar 

  • Mattson P, Svärdsudd K, Lundberg PO, Westerberg CE (2000) The prevalence of migraine in women aged 40–70 years: a population-based study. Cephalalgia 20:893–899

    Google Scholar 

  • McGettigan P, Henry D (2006) Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and non-selective inhibitors of cyclooxygenase 2. JAMA 296:1633–1644

    PubMed  CAS  Google Scholar 

  • McKellar G, Madhok R, Singh G (2008) Update on the use of analgesics versus nonsteroidal anti-inflammatory drugs in rheumatic disorders: risks and benefits. Curr Opin Rheumatol 20:239–245

    PubMed  CAS  Google Scholar 

  • McLean AJ, Le Couteur DG (2004) Aging biology and geriatric clinical pharmacology. Pharmacol Rev 56:163–184

    PubMed  CAS  Google Scholar 

  • Moore RA, Derry S, Makinson GT, McQuay HJ (2005) Tolerability and adverse events in clinical trials of celecoxib in osteoarthritis and rheumatoid arthritis: systematic review and meta-analysis of information from company clinical trial reports. Arthritis Res Ther 7:R644–R665

    PubMed  CAS  Google Scholar 

  • Moore RA, Derry S, Phillips CJ, McQuay HJ (2006) Nonsteroidal anti-inflammatory drugs (NSAIDs), cyxlooxygenase-2 selective inhibitors (coxibs) and gastrointestinal harm: review of clinical trials and clinical practice. BMC Musculoskelet Disord 7:79

    PubMed  Google Scholar 

  • Musson DG, Birk KL, Panebianco DL, Gagliano KD, Rogers JD, Goldberg MR (2001) Pharmacokinetics of rizatriptan in healthy elderly subjects. Int J Clin Pharmacol Ther 39:447–452

    PubMed  CAS  Google Scholar 

  • Nachit-Ouinekh F, Dartigues JF, Chrystosome V, Henry P, Sourgen C, El Hasnaoui A (2005) Evolution of migraine after a 10-year follow-up. Headache 45:1280–1287

    PubMed  Google Scholar 

  • Niccoli L, Bellino S, Cantini F (2002) Renal tolerability of three commonly employed non-steroidal anti-inflammatory drugs in elderly patients with osteoarthritis. Clin Exp Rheumatol 20:201–207

    PubMed  CAS  Google Scholar 

  • Noble M, Tregear SJ, Treadwell JR, Schoelles K (2008) Long-term opioid therapy for chronic noncancer pain: a systematic review and meta-analysis of efficacy and safety. J Pain Symptom Manage 35:214–228

    PubMed  Google Scholar 

  • Ofman JJ, MacLean CH, Straus WL, Morton SC, Berger ML, Roth EA, Shekelle PG (2002) A metaanalysis of severe upper gastrointestinal complications of nonsteroidal antiinflammatory drugs. J Rheumatol 29:804–812

    PubMed  CAS  Google Scholar 

  • Ofman JJ, MacLean CH, Straus WL, Morton SC, Berger ML, Roth EA, Shekelle PG (2003) Meta-analysis of dyspepsia and nonsteroidal antiinflammatory drugs. Arthritis Rheum 49:508–518

    PubMed  CAS  Google Scholar 

  • Opie LH (1997) Calcium channel blockers for hypertension. Dissecting the evidence for adverse events. Am J Hypertens 10:565–577

    PubMed  CAS  Google Scholar 

  • Owada K (2004) Efficacy of candesartan in the treatment of migraine in hypertensive patients. Hypertens Res 27:441–446

    PubMed  CAS  Google Scholar 

  • Pascual J, Berciano J (1994) Experience in the diagnosis of headaches that start in elderly people. J Neurol Neurosurg Psychiatry 57:1255–1257

    PubMed  CAS  Google Scholar 

  • Peck RW, Seaber EJ, Dixon RM, Layton GR, Weatherley BC, Jackson SH, Rolan PE, Posner J (1998) The pharmacodynamics and pharmacokinetics of the 5HT1B/1D-agonist zolmitriptan in healthy young and elderly men and women. Clin Pharmacol Ther 63:342–453

    PubMed  CAS  Google Scholar 

  • Prencipe M, Casini AR, Ferretti C, Santini M, Pezzella F, Scaldaferri N, Culasso F (2001) Prevalence of headache in an elderly population: attack frequency, disability, and use of medication. J Neurol Neurosurg Psychiatry 70:377–381

    PubMed  CAS  Google Scholar 

  • Punay NC, Couch JR (2003) Antidepressants in the treatment of migraine headache. Curr Pain Headache Rep 7:51–54

    PubMed  Google Scholar 

  • Rasmussen BK, Lipton RB (2006) Prognosis of migraines. In: Olesen J, Goadsby PJ, Ramadan NM, Tfelt-Hansen P, Welch KMA (eds) The headaches, 3rd edn. Lippincott Williams & Wilkins, Philadelphia, pp 429–431

    Google Scholar 

  • Rasmussen BK, Jensen R, Schroll M, Olesen J (1991) Epidemiology of headache in a general population: a prevalence study. J Clin Epidemiol 44:1147–1157

    PubMed  CAS  Google Scholar 

  • Reid MC, Engles-Horton LL, Weber MB, Kerns RD, Rogers EL, O'Connor PG (2002) Use of opioid medications for chronic noncancer pain syndromes in primary care. J Gen Intern Med 17:173–179

    PubMed  Google Scholar 

  • Richy F, Bruyere O, Ethgen O, Rabenda V, Bouvenot G, Audran M, Herrero-Beaumont G, Moore A, Eliakim R, Haim M, Reginster JY (2004) Time dependent risk of gastrointestinal complications induced by non-steroidal anti-inflammatory drug use: a consensus statement using a meta-analytic approach. Ann Rheum Dis 63:759–766

    PubMed  CAS  Google Scholar 

  • Rosenberg JH, Silberstein SD (2005) The headache of SAH responds to sumatriptan. Headache 45:597–598

    PubMed  Google Scholar 

  • Rostom A, Dube C, Wells G, Tugwell P, Welch V, Jolicoeur E, McGowan J (2002) Prevention of NSAID-induced gastroduodenal ulcers. Cochrane Database Syst Rev CD0022960

    Google Scholar 

  • Rowbotham M, Harden N, Stacey B, Bernstein P, Magnus-Miller L (1998) Gabapentin for the treatment of postherpetic neuralgia: a randomized controlled trial. JAMA 280:1837–1842

    PubMed  CAS  Google Scholar 

  • Santiago TV, Edelman NH (1985) Opioids and breathing. J Appl Physiol 59:1675–1685

    PubMed  CAS  Google Scholar 

  • Scher AI, Stewart WF, Ricci JA, Lipton RB (2003) Factors associated with the onset and remission of chronic daily headache in a population-based study. Pain 106:81–89

    PubMed  CAS  Google Scholar 

  • Scher AI, Stewart WF, Lipton RB (2004) Caffeine as a risk factor for chronic daily headache: a population-based study. Neurology 63:2022–2027

    PubMed  CAS  Google Scholar 

  • Schrader H, Stovner LJ, Helde G, Sand T, Bovim G (2001) Prophylactic treatment of migraine with angiotensin converting enzyme inhibitor (lisinopril): randomized, placebo controlled, crossover study. BMJ 322:1–5

    Google Scholar 

  • Schuh-Hofer S, Flach U, Meisel A, Israel H, Reuter U, Arnold G (2007) Efficacy of lisinopril in migraine prophylaxis—an open label study. Eur J Neurol 14:701–703

    PubMed  CAS  Google Scholar 

  • Schwaiger J, Kiechl S, Seppi K, Sawires M, Stockner H, Erlacher T, Mairhofer ML, Niederkofler H, Rungger G, Gasperi A, Poewe W, Willeit J (2002) Prevalence of primary headaches and cranial neuralgias in men and women aged 55–94 years (Bruneck Study). Cephalalgia 29:179–187

    Google Scholar 

  • Schwartz JB (1996) Calcium antagonists in the elderly. A risk–benefit analysis. Drugs Aging 9:24–36

    PubMed  CAS  Google Scholar 

  • Setakis E, Leufkens HG, van Staa TP (2008) Changes in the characteristics of patients prescribed selective cyclooxygenase-2 inhibitors after the 2004 withdrawal of rofecoxib. Arthritis Rheum 59:1105–1111

    PubMed  CAS  Google Scholar 

  • Silberstein SD, McCrory DC (2003) Ergotamine and dihydroergotamine: history, pharmacology, and efficacy. Headache 43:144–166

    PubMed  Google Scholar 

  • Silberstein S, Tepper S, Brandes J, Diamond M, Goldstein J, Winner P, Venkatraman S, Vrijens F, Malbecq W, Lines C, Visser WH, Reines S, Yuen E (2004) Randomized, placebo-controlled trial of rofecoxib in the acute treatment of migraine. Neurology 62:1552–1557

    PubMed  CAS  Google Scholar 

  • Singh G, Fort JG, Goldstein JL, Levy RA, Hanrahan PS, Bello AE, Andrade-Ortega L, Wallemark C, Agrawal NM, Eisen GM, Stenson WF, Triadafilopoulos G, SUCCESS-I Investigators (2006a) Celecoxib versus naproxen and diclofenac in osteoarthritis patients: SUCCESS-I Study. Am J Med 119:255–266

    PubMed  CAS  Google Scholar 

  • Singh G, Wu O, Langhorne P, Madhok R (2006b) Risk of acute myocardial infarction with nonselective non-steroidal anti-inflammatory drugs: a meta-analysis. Arthritis Res Ther 8:R153

    PubMed  Google Scholar 

  • Spiegel BM, Farid M, Dulai GS, Gralnek IM, Kanwal F (2006) Comparing rates of dyspepsia with Coxibs vs NSAID + PPI: a meta-analysis. Am J Med 119:448e427–448e436

    Google Scholar 

  • Stewart WF, Lipton RB, Celentano DD, Reed ML (1992) Prevalence of migraine headache in the United States. J Am Med Assoc 267:64–69

    CAS  Google Scholar 

  • Tfelt-Hansen P, Olesen J, Aebelholt-Krabbe A, Melgaard B, Veilis B (1980) A double blind study of metoclopramide in the treatment of migraine attacks. J Neurol Neurosurg Psychiatry 43:369–371

    PubMed  CAS  Google Scholar 

  • Tfelt-Hansen P, Henry P, Mulder LJ, Scheldewaert RG, Schoenen J, Chazot G (1995) The effectiveness of combined oral lysine acetylsalicylate and metoclopramide compared with oral sumatriptan for migraine. Lancet 346:923–926

    PubMed  CAS  Google Scholar 

  • Tfelt-Hansen P, Saxena PR, Dahlöf C, Pascual J, Láinez M, Henry P, Diener H, Schoenen J, Ferrari MD, Goadsby PJ (2000) Ergotamine in the acute treatment of migraine. A review and European consensus. Brain 123:9–18

    PubMed  Google Scholar 

  • Touchon J, Bertin L, Pilgrim AJ, Ashford E, Bes A (1996) A comparison of subcutaneous sumatriptan and dihydroergotamine nasal spray in the acute treatment of migraine. Neurology 47:361–365

    PubMed  CAS  Google Scholar 

  • Tronvik E, Stovner LJ, Helde G, Sand T, Bovim G (2003) Prophylactic treatment of migraine with an angiotensin II receptor blocker. A randomized controlled trial. JAMA 289:65–69

    PubMed  CAS  Google Scholar 

  • Ward TM (2002) Headache disorders in the elderly. Curr Treat Options Neurol 4:403–408

    PubMed  Google Scholar 

  • Whelton A, Fort JG, Puma JA, Normandin D, Bello AE, Verburg KM, SUCCESS VI Study Group (2001) Cyclooxygenase-2–specific inhibitors and cardiorenal function: a randomized, controlled trial of celecoxib and rofecoxib in older hypertensive osteoarthritis patients. Am J Ther 8:85–95

    PubMed  CAS  Google Scholar 

  • Wiffen PJ, McQuay HJ, Edwards JE, Moore RA (2005) Gabapentin for acute and chronic pain. Cochrane Database Syst Rev CD005452

    Google Scholar 

  • Zito G, Jull G, Story I (2006) Clinical tests of musculoskeletal dysfunction in the diagnosis of cervicogenic headache. Man Ther 11:118–129

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurology, University of L’Aquila, L’Aquila, Italy

    Dr. Simona Sacco & Dr. Antonio Carolei

Authors
  1. Dr. Simona Sacco
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dr. Antonio Carolei
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Simona Sacco .

Editor information

Editors and Affiliations

  1. Department of Medical and Molecular Sciences, School of Health Sciences, Sapienza University of Rome, Rome, Italy

    Paolo Martelletti

  2. Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway

    Timothy J. Steiner

  3. Department of Neuroscience, Faculty of Medicine, Imperial College London, London, UK

    Timothy J. Steiner

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Lifting The Burden

About this entry

Cite this entry

Sacco, S., Carolei, A. (2011). Managing Headache in Older People. In: Martelletti, P., Steiner, T.J. (eds) Handbook of Headache. Springer, Milano. https://doi.org/10.1007/978-88-470-1700-9_47

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-1700-9_47

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-1699-6

  • Online ISBN: 978-88-470-1700-9

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation