Abstract
Persistent Idiopathic Facial Pain (PIFP) is a moderate or severe continuous pain disorder in the facial region. The pain is usually deep and poorly localized, and the quality is of burning, cramping, or dull quality. The incidence is estimated to 2–4 per 100,000 but exact epidemiological data are lacking. Persistent idiopathic facial pain is a difficult diagnostic group compared to other pain categories and symptomatic causes must always be sought. The underlying pathophysiology is yet unknown and therapy is widely unspecific and ineffective. The existing literature is reviewed and summarized, the possible differential diagnoses are listed, and the existing treatment strategies are presented. The optimal outcome is achieved by a multidisciplinary approach focusing on a combination of symptomatic medication, patient education, cognitive therapy, and coping strategies. In conclusion, patients with PIFP remain a complicated group to diagnose and to treat. The scientific evidence for a specific entity, a clear pathophysiological mechanism and effective treatment strategies are still lacking. Further field testing and clinical characterizations of these severely affected patients are highly needed and the noncommittal title Persistent Idiopathic Facial Pain is preferable until further evidence is available.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Abrahamsen R, Baad-Hansen L, Svensson P (2008) Hypnosis in the management of persistent idiopathic orofacial pain – clinical and psychosocial findings. Pain 136(1–2):44–52. Epub 6 Aug 2007
Baad-Hansen L (2008) Atypical odontalgia – pathophysiology and clinical management. J Oral Rehabil 35(1):1–11
Baile WF Jr, Myers D (1986) Psychological and behavioral dynamics in chronic atypical facial pain. Anesth Prog 33(5):252–257
Balamucki CJ, Stieber VW, Ellis TL, Tatter SB, Deguzman AF, McMullen KP, Lovato J, Shaw EG, Ekstrand KE, Bourland JD, Munley MT, Robbins M, Branch C (2006) Does dose rate affect efficacy? The outcomes of 256 gamma knife surgery procedures for trigeminal neuralgia and other types of facial pain as they relate to the half-life of cobalt. J Neurosurg 105(5):730–735
Benoliel R, Eliav E (2008) Neuropathic orofacial pain. Oral Maxillofac Surg Clin North Am 20(2):237–254, vii
Brenoliel R, Birman N, Eliav E, Shrav Y (2008) The international classification of headache disorders accurate diagnosis of orofacial pain. Cephalalgia 28:752–762
Broggi G, Ferroli P, Franzini A, Galosi L (2005) The role of surgery in the treatment of typical and atypical facial pain. Neurol Sci 26(Suppl 2):s95–s100
Broggi G, Franzini A, Leone M, Bussone G (2007) Update on neurosurgical treatment of chronic trigeminal autonomic cephalalgias and atypical facial pain with deep brain stimulation of posterior hypothalamus: results and comments. Neurol Sci 28(Suppl 2):S138–S145
Cornelissen P, van Kleef M, Mekhail N, Day M, van Zundert J (2009) Evidence-based interventional pain medicine according to clinical diagnoses. 3. Persistent idiopathic facial pain. Pain Pract 9(6):443–448
Delvaux V, Schoenen J (2001) New generation anti-epileptics for facial pain and headache. Acta Neurol Belg 101(1):42–46
Derbyshire SW, Whalley MG, Stenger VA, Oakley DA (2004) Cerebral activation during hypnotically induced and imagined pain. Neuroimage 23(1):392–401
Evans RW, Agostoni E (2006) Persistent idiopathic facial pain. Headache 46(8):1298–1300
Forssell H, Tasmuth T, Tenovuo O, Hampf G, Kalso E (2004) Venlafaxine in the treatment of atypical facial pain: a randomized controlled trial. J Orofac Pain 18(2):131–137
Forssell H, Tenovuo O, Silvoniemi P, Jääskeläinen SK (2007) Differences and similarities between atypical facial pain and trigeminal neuropathic pain. Neurology 69(14):1451–1459
Graff-Radford SB (2009) Facial pain. Neurologist 15:171–177
Hagelberg N, Forssell H, Aalto S, Rinne JO, Scheinin H, Taiminen T, Någren K, Eskola O, Jääskeläinen SK (2003) Altered dopamine D2 receptor binding in atypical facial pain. Pain 106(1–2):43–48
Headache Classification Committee of the International Headache Society (2004) Classification and diagnostic criteria for headache disorders, cranial neuralgia and facial pain, 2nd Edition. Cephalalgia 24(Suppl 1):1–164
Hillerup S, Jensen R (2006) Nerve injury caused by mandibular block analgesia. Int J Oral Maxillofac Surg 35:437–443
Hillerup S, Jensen R, Ersbøll B (2011) Trigeminal nerve injury associated with injection of local anaesthetics. Needle lesion or neurotoxicity? [Epub ahead of print]
Koopman JS, Dieleman JP, Huygen FJ, de Mos M, Martin CG, Sturkenboom MC (2009) Incidence of facial pain in the general population. Pain 147(1–3):122–127
Lang E, Naraghi R, Tanrikulu L, Hastreiter P, Fahlbusch R, Neundörfer B, Tröscher-Weber R (2005) Neurovascular relationship at the trigeminal root entry zone in persistent idiopathic facial pain: findings from MRI 3D visualisation. J Neurol Neurosurg Psychiatry 76(11):1506–1509
List T, Leijon G, Svensson P (2008) Somatosensory abnormalities in atypical odontalgia: a case-control study. Pain 139(2):333–341
Madland G, Feinmann C (2001) Chronic facial pain: a multidisciplinary problem. J Neurol Neurosurg Psychiatry 71(6):716–719
Sardella A, Demarosi F, Barbieri C, Lodi G (2009) An up-to-date view on persistent idiopathic facial pain. Minerva Stomatol 58(6):289–299
Sato J, Saitoh T, Notani K, Fukuda H, Kaneyama K, Segami N (2004) Diagnostic significance of carbamazepine and trigger zones in trigeminal neuralgia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97(1):18–22
Schmidt-Wilcke T, Hierlmeier S, Leinisch E (2010) Altered regional brain morphology in patients with chronic facial pain. Headache 50(8):1278–1285. [Epub ahead of print 5 Mar 2010]
Teixeira MJ, Siqueira SR, Almeida GM (2006) Percutaneous radiofrequency rhizotomy and neurovascular decompression of the trigeminal nerve for the treatment of facial pain. Arq Neuropsiquiatr 64(4):983–989
Volcy M, Rapoport AM, Tepper SJ, Sheftell FD, Bigal ME (2006) Persistent idiopathic facial pain responsive to topiramate. Cephalalgia 26(4):489–491
Woda A, Pionchon P (2000) A unified concept of idiopathic orofacial pain: pathophysiologic features. J Orofac Pain 14(3):196–212
Zebenholzer K, Wöber C, Vigl M, Wessely P, Wöber-Bingöl C (2005) Facial pain in a neurological tertiary care centre – evaluation of the international classification of headache disorders. Cephalalgia 25:689–699
Zebenholzer K, Wöber C, Vigl M, Wessely P, Wöber-Bingöl C (2006) Facial pain and the second edition of the international classification of headache disorders. Headache 46:259–263
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Lifting The Burden
About this entry
Cite this entry
Jensen, R., Mitsikostas, D.D., Wöber, C. (2011). Persistent Idiopathic Facial Pain. In: Martelletti, P., Steiner, T.J. (eds) Handbook of Headache. Springer, Milano. https://doi.org/10.1007/978-88-470-1700-9_40
Download citation
DOI: https://doi.org/10.1007/978-88-470-1700-9_40
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-1699-6
Online ISBN: 978-88-470-1700-9
eBook Packages: MedicineReference Module Medicine