Abstract
The acute and preventive medical treatment of patients with primary headache syndromes such as chronic migraine is challenging and side effects frequently complicate the course of medical treatment. Recently there has been considerable progress in neurostimulation techniques in medically intractable chronic headache syndromes. It is very well known that a non-painful stimulation of peripheral nerves can elicit analgesic effects. This phenomenon has been used in certain pain syndromes using non-invasive high- or low-frequency transcutaneous electrical nerve stimulation (TENS), percutaneous electrical nerve stimulation (PENS/acupuncture-like TENS or AL-TENS), and spinal cord stimulation (SCS). The analgesic effect is critically dependent on the intensity of the electrical stimulation. In recent years, minimally invasive neurostimulation techniques and neuromodulatory techniques, such as transcranial magnetic stimulation, have also been applied to patients with chronic headaches. This chapter summarizes the current concepts and outcome data of neurostimulation and neuromodulatory approaches. The studies suggest suboccipital neurostimulation can have an effect even decades after onset of headaches thus representing a possible therapeutic option in chronic patients with headaches difficult to treat and that do not respond to any medication. In a subset of patients with chronic cluster headaches, hypothalamic deep brain stimulation may be a treatment option.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Bahra A, Matharu MS et al (2001) Brainstem activation specific to migraine headache. Lancet 357(9261):1016–1017
Bartsch T, Knight YE et al (2004a) Activation of 5-HT1B/1D receptors in the periaqueductal grey inhibits meningeal nociception. Ann Neurol 56(3):371–381
Bartsch T, Levy MJ et al (2004b) Differential modulation of dural nociception to Orexin A and B receptor activation in the posterior hypothalamic area. Pain 109:367–378
Bartsch T, Levy MJ et al (2005) Inhibition of nociceptive dural input in the trigeminal nucleus caudalis by somatostatin receptor blockade in the posterior hypothalamus. Pain 117(1–2):30–39
Bartsch T, Paemeleire K et al (2009) Neurostimulation approaches to primary headache disorders. Curr Opin Neurol 22(3):262–268
Behbehani MM (1995) Functional characteristics of the midbrain periaqueductal gray. Prog Neurobiol 46(6):575–605
Burns B, Watkins L et al (2008) Treatment of hemicrania continua by occipital nerve stimulation with a bion device: long-term follow-up of a crossover study. Lancet Neurol 7(11):1001–1012
Burns B, Watkins L et al (2009) Treatment of intractable chronic cluster headache by occipital nerve stimulation in 14 patients. Neurology 72(4):341–345
Choi CR, Umbach W (1977) Combined stereotaxic surgery for relief of intractable pain. Neurochirurgia (Stuttg) 20(3):84–87
Chung JM, Lee KH et al (1984) Factors influencing peripheral nerve stimulation produced inhibition of primate spinothalamic tract cells. Pain 19(3):277–293
Cohen AS, Goadsby PJ (2006) Functional neuroimaging of primary headache disorders. Expert Rev Neurother 6(8):1159–1171
Cortelli P, Guaraldi P et al (2007) Effect of deep brain stimulation of the posterior hypothalamic area on the cardiovascular system in chronic cluster headache patients. Eur J Neurol 14(9):1008–1015
Doubell T, Mannion RJ, Woolf CJ (1999) The doral horn: state dependent sensory processing, plasticity and the generation of pain. In: Melzack PDWR (ed) Textbook of pain, vol 59, 4th edn. Churchill Livingstone, Edinburgh, pp 165–180
Duggan AW, Foong FW (1985) Bicuculline and spinal inhibition produced by dorsal column stimulation in the cat. Pain 22(3):249–259
Fontaine D, Lanteri-Minet M et al (2010a) Anatomical location of effective deep brain stimulation electrodes in chronic cluster headache. Brain 133(4):1214–1223
Fontaine D, Lazorthes Y et al (2010b) Safety and efficacy of deep brain stimulation in refractory cluster headache: a randomized placebo-controlled double-blind trial followed by a 1-year open extension. J Headache Pain 11(1):23–31
Franzini A, Ferroli P et al (2003) Stimulation of the posterior hypothalamus for treatment of chronic intractable cluster headaches: first reported series. Neurosurgery 52(5):1095–1099, discussion 1099–1101
Garrison D, Foreman R (1994) Decreased activity of spontaneous and noxiously evoked dorsal horn cells during transcutaneous electrical nerve stimulation (TENS). Pain 58(3):309–315
Garrison DW, Foreman RD (1996) Effects of transcutaneous electrical nerve stimulation (TENS) on spontaneous and noxiously evoked dorsal horn cell activity in cats with transected spinal cords. Neurosci Lett 216(2):125–128
Gildenberg PL, Murthy KS (1980) Influence of dorsal column stimulation upon human thalamic somatosensory-evoked potentials. Appl Neurophysiol 43(1–2):8–17
Goadsby PJ (2007) Neurostimulation in primary headache syndromes. Expert Rev Neurother 7(12):1785–1789
Goadsby PJ, Schoenen J et al (2006) Towards a definition of intractable headache for use in clinical practice and trials. Cephalalgia 26(9):1168–1170
Goadsby PJ, Bartsch T et al (2008a) Occipital nerve stimulation for headache: mechanisms and efficacy. Headache 48(2):313–318
Goadsby PJ, Cittadini E et al (2008b) Trigeminal autonomic cephalalgias: diagnostic and therapeutic developments. Curr Opin Neurol 21(3):323–330
Goadsby PJ, Dodick DW, Saper JR, Silberstein SD (2009) Occipital nerve stimulation (ONS) for the treatment of intractable chronic migraine (ONSTIM). Cephalalgia 29:133
Headache Classification Committee of The International Headache Society (2004) The International Classification of Headache Disorders (second edition). Cephalalgia 24(Suppl 1):1–160
Holstege G (1987) Some anatomical observations on the projections from the hypothalamus to brainstem and spinal cord: an HRP and autoradiographic tracing study in the cat. J Comp Neurol 260(1):98–126
Ignelzi RJ, Nyquist JK (1979) Excitability changes in peripheral nerve fibers after repetitive electrical stimulation. Implications in pain modulation. J Neurosurg 51(6):824–833
Jarrar RG, Black DF et al (2003) Outcome of trigeminal nerve section in the treatment of chronic cluster headache. Neurology 60(8):1360–1362
Knight YE, Bartsch T et al (2003) Trigeminal antinociception induced by bicuculline in the periaqueductal gray (PAG) is not affected by PAG P/Q-type calcium channel blockade in rat. Neurosci Lett 336(2):113–116
Kolmodin GM, Skoglund CR (1960) Analysis of spinal interneurons activated by tactile and nociceptive stimulation. Acta Physiol Scand 50:337–355
Leone M, May A et al (2004) Deep brain stimulation for intractable chronic cluster headache: proposals for patient selection. Cephalalgia 24(11):934–937
Leone M, Franzini A et al (2005) Deep brain stimulation to relieve drug-resistant SUNCT. Ann Neurol 57(6):924–927
Leone M, Franzini A et al (2006) Acute hypothalamic stimulation and ongoing cluster headache attacks. Neurology 67(10):1844–1845
Lindblom U, Tapper DN et al (1977) The effect of dorsal column stimulation on the nociceptive response of dorsal horn cells and its relevance for pain suppression. Pain 4(2):133–144
Linderoth B, Foreman RD (1999) Physiology of spinal cord stimulation: review and update. Neuromodulation 2(3):150–164
Linderoth B, Foreman RD (2006) Mechanisms of spinal cord stimulation in painful syndromes: role of animal models. Pain Med 7(S1):S14–S26
Lyons MK, Dodick DW et al (2008) Responsiveness of short-lasting unilateral neuralgiform headache with conjunctival injection and tearing to hypothalamic deep brain stimulation. J Neurosurg 110:279–281
Magis D, Allena M et al (2007) Occipital nerve stimulation for drug-resistant chronic cluster headache: a prospective pilot study. Lancet Neurol 6(4):314–321
Matharu MS, Boes CJ et al (2002) SUNCT syndrome: prolonged attacks, refractoriness and response to topiramate. Neurology 58(8):1307
Matharu M, Bartsch T et al (2004) Central neuromodulation in chronic migraine patients with suboccipital stimulators: A PET study. Brain 127(1):220–230
May A, Leone M et al (2006) Hypothalamic deep brain stimulation in positron emission tomography. J Neurosci 26(13):3589–3593
Mayanagi Y, Bouchard G (1976) Evaluation of stereotactic thalamotomies for pain relief with reference to pulvinar intervention. Appl Neurophysiol 39(3–4):154–157
Oh MY, Ortega J, Bradley Bellotte J, Whiting DM, Aló K (2004) Peripheral nerve stimulation for the treatment of occipital neuralgia and transformed migraine using a C1-2-3 subcutaneous paddle style electrode: a technical report. Neuromodulation 7(2):103–112
Olausson B, Xu ZQ et al (1994) Dorsal column inhibition of nociceptive thalamic cells mediated by gamma-aminobutyric acid mechanisms in the cat. Acta Physiol Scand 152(3):239–247
Paemeleire K, Van Buyten JP, Van Buynder M, Alicino D, Van Maele G, Smet I, Goadsby PJ (2008) Phenotype of patients responsive to sub-occipital neurostimulation for refractory head pain. Eur J Neurol 15(suppl 3):10
Schoenen J, Di Clemente L et al (2005) Hypothalamic stimulation in chronic cluster headache: a pilot study of efficacy and mode of action. Brain 128(Pt 4):940–947
Schwedt TJ, Dodick DW et al (2007a) Occipital nerve stimulation for chronic headache–long-term safety and efficacy. Cephalalgia 27(2):153–157
Schwedt TJ, Dodick DW et al (2007b) Response to occipital nerve block is not useful in predicting efficacy of occipital nerve stimulation. Cephalalgia 27(3):271–274
Starr PA (2008) Commentary on Leone M et al., Lessons from 8 years' experience of hypothalamic stimulation in cluster headache. Cephalalgia 28(7):798
Starr PA, Barbaro NM et al (2007) Chronic stimulation of the posterior hypothalamic region for cluster headache: technique and 1-year results in four patients. J Neurosurg 106(6):999–1005
Stiller CO, Linderoth B et al (1995) Repeated spinal cord stimulation decreases the extracellular level of gamma-aminobutyric acid in the periaqueductal gray matter of freely moving rats. Brain Res 699(2):231–241
Stiller CO, Cui JG et al (1996) Release of gamma-aminobutyric acid in the dorsal horn and suppression of tactile allodynia by spinal cord stimulation in mononeuropathic rats. Neurosurgery 39(2):367–374, discussion 374–375
Trentman TL, Zimmerman RS (2008) Occipital nerve stimulation: technical and surgical aspects of implantation. Headache 48(2):319–327
Veazey RB, Amaral DG et al (1982) The morphology and connections of the posterior hypothalamus in the cynomolgus monkey (Macaca fascicularis). II. Efferent connections. J Comp Neurol 207(2):135–156
Vetrugno R, Pierangeli G et al (2007) Effect on sleep of posterior hypothalamus stimulation in cluster headache. Headache 47(7):1085–1090
Wall PD (1978) The gate control theory of pain mechanisms. A re-examination and re-statement. Brain 101(1):1–18
Weiller C, May A et al (1995) Brain stem activation in spontaneous human migraine attacks. Nat Med 1(7):658–660
Weiner R, Reed K (1999) Peripheral neurostimulation for control of intractable occipital neuralgia. Neuromodulation 2:217–221
Woolf CJ (1979) Transcutaneous electrical nerve stimulation and the reaction to experimental pain in human subjects. Pain 7(2):115–127
Woolf C, Thompson J (1994) Stimulation-induced analgesia: Transcutaneous electrical nerve stimulation (TENS) and vibration. In: Wall P, Melzack R (eds) Textbook of pain. Churchill Livingstone, New York, pp 1191–2008
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Lifting The Burden
About this entry
Cite this entry
Bartsch, T. (2011). Neurostimulation for Headache That Has Become Difficult to Treat. In: Martelletti, P., Steiner, T.J. (eds) Handbook of Headache. Springer, Milano. https://doi.org/10.1007/978-88-470-1700-9_34
Download citation
DOI: https://doi.org/10.1007/978-88-470-1700-9_34
Publisher Name: Springer, Milano
Print ISBN: 978-88-470-1699-6
Online ISBN: 978-88-470-1700-9
eBook Packages: MedicineReference Module Medicine