Treatment and Prevention of Migraine

  • Paolo Martelletti
  • Ivano Farinelli
Reference work entry


Migraine exerts a significant impact on quality of life. Several drugs are available for acute therapy of migraine attacks, namely, specific such as triptans or generic such as analgesics/anti-inflammatory. In some cases, prophylaxis therapy is taken into account according to both attack frequency and severity. In the past, the most common criterion applied for prophylaxis therapy was represented by the number of attacks per month. Considering such a pattern essential, the suggested number of attacks per month was of five or more episodes. At a later date, demand for prophylaxis also considered consumption of symptomatic drugs as well as increase of migraine frequency in a short period of time. Today, prophylaxis therapy is evaluated according to its impact on patients. Therefore, a general evaluation of the patient in terms of functional disability and quality of life is required to assess the appropriateness of prophylaxis therapy, as well as evaluating the risk of medication overuse or the presence of concomitant pathologies (e.g., hypertension, depression, epilepsy). Furthermore, in cases where the condition reaches a level of chronicity (chronic migraine), new options are available today in prophylaxis therapy.


Migraine Attack Chronic Migraine Naproxen Sodium Preventive Therapy Sodium Valproate 
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Copyright information

© Lifting The Burden 2011

Authors and Affiliations

  1. 1.Department of Medical and Molecular SciencesSchool of Health Sciences, Sapienza University of RomeRomeItaly

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