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Comorbidities of Headache Disorders

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Handbook of Headache

Abstract

Headaches are common disorders and migraine is most intensively investigated due to its high prevalence and often highly disabling character. Many conditions that are likewise prevalent have been described comorbid with migraine, and an increase of many comorbid conditions is seen among those with migraine with aura and higher frequency of headache. Well-established comorbidities include cardiovascular, psychiatric, neurological, and other pain disorders. With regard to cardiovascular disorders an association between migraine with aura and ischemic stroke has been most consistently described. Migraine with aura confers a twofold increased risk. Younger age, female gender, smoking, and oral contraceptive use seem to further raise the risk among migraineurs. With regard to psychiatric disorders, those with migraine are at increased risk of major depression, anxiety, panic disorder, bipolar disorder, abuse and neglect, and suicidal ideation or attempts. Common neurologic comorbidities include epilepsy and restless leg syndrome. Potential explanations for increased comorbidities will be explored. The complex network of an association between migraine and many other comorbid conditions is likely due to shared genetic factors that are further modified by environmental factors.

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References

  • Adami A, Rossato G, Cerini R, Thijs VN, Pozzi-Mucelli R, Anzola GP, Del Sette M, Finocchi C, Meneghetti G, Zanferrari C, Group SAMS (2008) Right-to-left shunt does not increase white matter lesion load in migraine with aura patients. Neurology 71:101–107

    PubMed  CAS  Google Scholar 

  • Ahmed B, Bairey Merz CN, McClure C, Johnson BD, Reis SE, Bittner V, Pepine CJ, Sharaf BL, Sopko G, Kelsey SF, Shaw L (2006) Migraines, angiographic coronary artery disease and cardiovascular outcomes in women. Am J Med 119:670–675

    PubMed  Google Scholar 

  • Ashina S, Buse DC, Maizels M, Manack A, Serrano D, Turkel C, Lipton RB (2010a) Depression: a risk factor for migraine chronification: results from the American Migraine Prevalence and Prevention (AMPP) study. 62nd Annual Meeting of the American Academy of Neurology, Toronto

    Google Scholar 

  • Ashina S, Buse DC, Maizels M, Manack A, Serrano D, Turkel CC, Lipton RB (2010b) Self-reported anxiety as a risk factor for migraine chronification. Results from the American Migraine Prevalence and Prevention (AMPP) study. 52nd Annual Scientific Meeting of the American Headache Society, Los Angeles

    Google Scholar 

  • Baskin SM, Smitherman TA (2009) Migraine and psychiatric disorders: comorbidities, mechanisms, and clinical applications. Neurol Sci 30(Suppl 1):S61–S65

    PubMed  Google Scholar 

  • Bekkelund SI, Salvesen R (2003) Prevalence of head trauma in patients with difficult headache: the North Norway Headache Study. Headache 43:59–62

    PubMed  Google Scholar 

  • Bianchi A, Pitari G, Amenta V, Giuliano F, Gallina M, Costa R, Ferlito S (1996) Endothelial, haemostatic and haemorheological modifications in migraineurs. Artery 22:93–100

    PubMed  CAS  Google Scholar 

  • Bigal ME, Lipton RB (2006a) Modifiable risk factors for migraine progression. Headache 46:1334–1343

    PubMed  Google Scholar 

  • Bigal ME, Lipton RB (2006b) Obesity is a risk factor for transformed migraine but not chronic tension-type headache. Neurology 67:252–257

    PubMed  Google Scholar 

  • Bigal ME, Liberman JN, Lipton RB (2006) Obesity and migraine: a population study. Neurology 66:545–550

    PubMed  Google Scholar 

  • Bigal ME, Kurth T, Santanello N, Buse D, Golden W, Robbins M, Lipton RB (2010) Migraine and cardiovascular disease: a population-based study. Neurology 74:628–635

    PubMed  CAS  Google Scholar 

  • Breslau N (1992) Migraine, suicidal ideation, and suicide attempts. Neurology 42:392–395

    PubMed  CAS  Google Scholar 

  • Breslau N (1998) Psychiatric comorbidity in migraine. Cephalalgia 18(Suppl 22):56–58, discussion 58-61

    PubMed  Google Scholar 

  • Breslau N, Davis GC (1993) Migraine, physical health and psychiatric disorder: a prospective epidemiologic study in young adults. J Psychiatr Res 27:211–221

    PubMed  CAS  Google Scholar 

  • Breslau N, Rasmussen BK (2001) The impact of migraine: Epidemiology, risk factors, and co-morbidities. Neurology 56:S4–S12

    PubMed  CAS  Google Scholar 

  • Breslau N, Davis GC, Andreski P (1991) Migraine, psychiatric disorders, and suicide attempts: an epidemiologic study of young adults. Psychiatry Res 37:11–23

    PubMed  CAS  Google Scholar 

  • Breslau N, Davis GC, Schultz LR, Peterson EL (1994a) Joint 1994 Wolff Award Presentation. Migraine and major depression: a longitudinal study. Headache 34:387–393

    PubMed  CAS  Google Scholar 

  • Breslau N, Merikangas K, Bowden CL (1994b) Comorbidity of migraine and major affective disorders. Neurology 44:S17–S22

    PubMed  CAS  Google Scholar 

  • Breslau N, Schultz LR, Stewart WF, Lipton RB, Lucia VC, Welch KM (2000) Headache and major depression: is the association specific to migraine? Neurology 54:308–313

    PubMed  CAS  Google Scholar 

  • Brodtkorb E, Bakken IJ, Sjaastad O (2008) Comorbidity of migraine and epilepsy in a Norwegian community. Eur J Neurol 15:1421–1423

    PubMed  CAS  Google Scholar 

  • Buse DC, Manack A, Serrano D, Turkel C, Lipton RB (2010) Sociodemographic and comorbidity profiles of chronic migraine and episodic migraine sufferers. J Neurol Neurosurg Psychiatry. doi:10.1136/jnnp. 2009.192492

    PubMed  Google Scholar 

  • Casas JP, Hingorani AD, Bautista LE, Sharma P (2004) Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls. Arch Neurol 61:1652–1661

    PubMed  Google Scholar 

  • Chen PK, Fuh JL, Chen SP, Wang SJ (2010) Association between restless legs syndrome and migraine. J Neurol Neurosurg Psychiatry 81(5):524–528

    PubMed  Google Scholar 

  • Clarke T, Baskurt Z, Strug LJ, Pal DK (2009) Evidence of shared genetic risk factors for migraine and rolandic epilepsy. Epilepsia 50:2428–2433

    PubMed  Google Scholar 

  • Collaborative Group for the Study of Stroke in Young Women (1975) Oral contraceptives and stroke in young women. Associated risk factors. JAMA 231:718–722

    Google Scholar 

  • Couch JR, Bearss C (2001) Chronic daily headache in the posttrauma syndrome: relation to extent of head injury. Headache 41:559–564

    PubMed  CAS  Google Scholar 

  • Couch JR, Lipton RB, Stewart WF, Scher AI (2007) Head or neck injury increases the risk of chronic daily headache: a population-based study. Neurology 69:1169–1177

    PubMed  Google Scholar 

  • D’Andrea G, Toldo M, Cortelazzo S, Milone FF (1982) Platelet activity in migraine. Headache 22:207–212

    PubMed  Google Scholar 

  • Del Sette M, Dinia L, Bonzano L, Roccatagliata L, Finocchi C, Parodi RC, Sivori G, Gandolfo C (2008) White matter lesions in migraine and right-to-left shunt: a conventional and diffusion MRI study. Cephalalgia 28:376–382

    PubMed  CAS  Google Scholar 

  • Diener HC, Kurth T, Dodick D (2007) Patent foramen ovale, stroke, and cardiovascular disease in migraine. Curr Opin Neurol 20:310–319

    PubMed  Google Scholar 

  • Donaghy M, Chang CL, Poulter N (2002) Duration, frequency, recency, and type of migraine and the risk of ischaemic stroke in women of childbearing age. J Neurol Neurosurg Psychiatry 73:747–750

    PubMed  CAS  Google Scholar 

  • Dworkin SF, Von Korff M, LeResche L (1990) Multiple pains and psychiatric disturbance An epidemiologic investigation. Arch Gen Psychiatry 47:239–244

    PubMed  CAS  Google Scholar 

  • Etminan M, Takkouche B, Isorna FC, Samii A (2005) Risk of ischaemic stroke in people with migraine: systematic review and meta-analysis of observational studies. BMJ 330:63

    PubMed  Google Scholar 

  • Feinstein AR (1970) The pretherapeutic classification of comorbidity in chronic disease. J Chron Dis 23:455–468

    Google Scholar 

  • Fiermonte G, Annulli A, Pierelli F (1999) Transcranial Doppler evaluation of cerebral hemodynamics in migraineurs during prophylactic treatment with flunarizine. Cephalalgia 19:492–496

    PubMed  CAS  Google Scholar 

  • Fuh JL, Wang SJ, Juang KD, Lu SR, Liao YC, Chen SP (2010) Relationship between childhood physical maltreatment and migraine in adolescents. Headache 50:761–768

    PubMed  Google Scholar 

  • Garg P, Servoss SJ, Wu JC, Bajwa ZH, Selim MH, Dineen A, Kuntz RE, Cook EF, Mauri L (2010) Lack of association between migraine headache and patent foramen ovale: results of a case-control study. Circulation 121:1406–1412

    PubMed  Google Scholar 

  • Gomi S, Gotoh F, Komatsumoto S, Ishikawa Y, Araki N, Hamada J (1989) Sweating function and retinal vasomotor reactivity in migraine. Cephalalgia 9:179–185

    PubMed  CAS  Google Scholar 

  • Guidetti V, Galli F, Fabrizi P, Giannantoni AS, Napoli L, Bruni O, Trillo S (1998) Headache and psychiatric comorbidity: clinical aspects and outcome in an 8-year follow-up study. Cephalalgia 18:455–462

    PubMed  CAS  Google Scholar 

  • Hagen K, Einarsen C, Zwart JA, Svebak S, Bovim G (2002) The co-occurrence of headache and musculoskeletal symptoms amongst 51 050 adults in Norway. Eur J Neurol 9:527–533

    PubMed  CAS  Google Scholar 

  • Hall GC, Brown MM, Mo J, MacRae KD (2004) Triptans in migraine: the risks of stroke, cardiovascular disease, and death in practice. Neurology 62:563–568

    PubMed  CAS  Google Scholar 

  • Hamelsky SW, Lipton RB (2006) Psychiatric comorbidity of migraine. Headache 46:1327–1333

    PubMed  Google Scholar 

  • Haut SR, Bigal ME, Lipton RB (2006) Chronic disorders with episodic manifestations: focus on epilepsy and migraine. Lancet Neurol 5:148–157

    PubMed  Google Scholar 

  • Henrich JB, Horwitz RI (1989) A controlled study of ischemic stroke risk in migraine patients. J Clin Epidemiol 42:773–780

    PubMed  CAS  Google Scholar 

  • Hering-Hanit R, Friedman Z, Schlesinger I, Ellis M (2001) Evidence for activation of the coagulation system in migraine with aura. Cephalalgia 21:137–139

    PubMed  CAS  Google Scholar 

  • Juang KD, Wang SJ, Fuh JL, Lu SR, Su TP (2000) Comorbidity of depressive and anxiety disorders in chronic daily headache and its subtypes. Headache 40:818–823

    PubMed  CAS  Google Scholar 

  • Kastrup A, Thomas C, Hartmann C, Schabet M (1998) Cerebral blood flow and CO2 reactivity in interictal migraineurs: a transcranial Doppler study. Headache 38:608–613

    PubMed  CAS  Google Scholar 

  • Kruit MC, van Buchem MA, Hofman PA, Bakkers JT, Terwindt GM, Ferrari MD, Launer LJ (2004) Migraine as a risk factor for subclinical brain lesions. JAMA 291:427–434

    PubMed  CAS  Google Scholar 

  • Kruit MC, Launer LJ, Ferrari MD, van Buchem MA (2006) Brain stem and cerebellar hyperintense lesions in migraine. Stroke 37:1109–1112

    PubMed  Google Scholar 

  • Kurth T (2007) Migraine and ischaemic vascular events. Cephalalgia 27:967–975

    Google Scholar 

  • Kurth T, Slomke MA, Kase CS, Cook NR, Lee IM, Gaziano JM, Diener HC, Buring JE (2005) Migraine, headache, and the risk of stroke in women: a prospective study. Neurology 64:1020–1026

    PubMed  CAS  Google Scholar 

  • Kurth T, Gaziano JM, Cook NR, Logroscino G, Diener HC, Buring JE (2006) Migraine and risk of cardiovascular disease in women. JAMA 296:283–291

    PubMed  CAS  Google Scholar 

  • Kurth T, Gaziano JM, Cook NR, Bubes V, Logroscino G, Diener HC, Buring JE (2007) Migraine and risk of cardiovascular disease in men. Arch Intern Med 167:795–801

    PubMed  Google Scholar 

  • Kurth T, Ridker P, Buring J (2008a) Migraine and biomarkers of cardiovascular disease. Cephalalgia 28:49–56

    PubMed  CAS  Google Scholar 

  • Kurth T, Schürks M, Logroscino G, Gaziano JM, Buring JE (2008b) Migraine, vascular risk, and cardiovascular events in women: prospective cohort study. BMJ 337:a636

    PubMed  Google Scholar 

  • Kurth T, Schürks M, Logroscino G, Buring JE (2009) Migraine frequency and risk of cardiovascular disease in women. Neurology 73:581–588

    PubMed  Google Scholar 

  • Lanteri-Minet M, Radat F, Chautard MH, Lucas C (2005) Anxiety and depression associated with migraine: influence on migraine subjects’ disability and quality of life, and acute migraine management. Pain 118:319–326

    PubMed  Google Scholar 

  • Lee ST, Chu K, Jung KH, Kim DH, Kim EH, Choe VN, Kim JH, Im WS, Kang L, Park JE, Park HJ, Park HK, Song EC, Lee SK, Kim M, Roh JK (2008) Decreased number and function of endothelial progenitor cells in patients with migraine. Neurology 70:1510–1517

    PubMed  Google Scholar 

  • Leniger T, von den Driesch S, Isbruch K, Diener HC, Hufnagel A (2003) Clinical characteristics of patients with comorbidity of migraine and epilepsy. Headache 43:672–677

    PubMed  Google Scholar 

  • Lewis SJ, Ebrahim S, Davey Smith G (2005) Meta-analysis of MTHFR 677C->T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate? BMJ 331:1053

    PubMed  CAS  Google Scholar 

  • Liew G, Wang JJ, Mitchell P (2007) Migraine and coronary heart disease mortality: a prospective cohort study. Cephalalgia 27:368–371

    PubMed  CAS  Google Scholar 

  • Lipton RB, Silberstein SD (1994) Why study the comorbidity of migraine? Neurology 44:S4–S5

    PubMed  CAS  Google Scholar 

  • Low NC, Du Fort GG, Cervantes P (2003) Prevalence, clinical correlates, and treatment of migraine in bipolar disorder. Headache 43:940–949

    PubMed  Google Scholar 

  • Lu SR, Fuh JL, Juang KD, Wang SJ (2000) Repetitive intravenous prochlorperazine treatment of patients with refractory chronic daily headache. Headache 40:724–729

    PubMed  CAS  Google Scholar 

  • Lu SR, Fuh JL, Chen WT, Juang KD, Wang SJ (2001) Chronic daily headache in Taipei, Taiwan: prevalence, follow-up and outcome predictors. Cephalalgia 21:980–986

    PubMed  CAS  Google Scholar 

  • Ludvigsson P, Hesdorffer D, Olafsson E, Kjartansson O, Hauser WA (2006) Migraine with aura is a risk factor for unprovoked seizures in children. Ann Neurol 59:210–213

    PubMed  Google Scholar 

  • MacClellan LR, Giles W, Cole J, Wozniak M, Stern B, Mitchell BD, Kittner SJ (2007) Probable migraine with visual aura and risk of ischemic stroke: the stroke prevention in young women study. Stroke 38:2438–2445

    PubMed  Google Scholar 

  • Mahmood T, Romans S, Silverstone T (1999) Prevalence of migraine in bipolar disorder. J Affect Disord 52:239–241

    PubMed  CAS  Google Scholar 

  • McWilliams LA, Goodwin RD, Cox BJ (2004) Depression and anxiety associated with three pain conditions: results from a nationally representative sample. Pain 111:77–83

    PubMed  Google Scholar 

  • Merikangas KR, Risch NJ, Merikangas JR, Weissman MM, Kidd KK (1988) Migraine and depression: association and familial transmission. J Psychiatr Res 22:119–129

    PubMed  CAS  Google Scholar 

  • Merikangas KR, Angst J, Isler H (1990) Migraine and psychopathology. Results of the Zurich cohort study of young adults. Arch Gen Psychiatry 47:849–853

    PubMed  CAS  Google Scholar 

  • Merikangas KR, Whitaker AE, Isler H, Angst J (1994) The Zurich Study: XXIII. Epidemiology of headache syndromes in the Zurich cohort study of young adults. Eur Arch Psychiatry Clin Neurosci 244:145–152

    PubMed  CAS  Google Scholar 

  • Napoli R, Guardasole V, Zarra E, Matarazzo M, D’Anna C, Sacca F, Affuso F, Cittadini A, Carrieri PB, Sacca L (2009) Vascular smooth muscle cell dysfunction in patients with migraine. Neurology 72:2111–2114

    PubMed  CAS  Google Scholar 

  • Nozari A, Dilekoz E, Sukhotinsky I, Stein T, Eikermann-Haerter K, Liu C, Wang Y, Frosch MP, Waeber C, Ayata C, Moskowitz MA (2010) Microemboli may link spreading depression, migraine aura, and patent foramen ovale. Ann Neurol 67:221–229

    PubMed  Google Scholar 

  • O’Keeffe ST, Tsapatsaris NP, Beetham WP Jr (1993) Association between Raynaud’s phenomenon and migraine in a random population of hospital employees. J Rheumatol 20:1187–1188

    PubMed  Google Scholar 

  • Ottman R, Lipton RB (1996) Is the comorbidity of epilepsy and migraine due to a shared genetic susceptibility? Neurology 47:918–924

    PubMed  CAS  Google Scholar 

  • Pesa J, Lage MJ (2004) The medical costs of migraine and comorbid anxiety and depression. Headache 44:562–570

    PubMed  Google Scholar 

  • Peterlin BL (2009) Post-traumatic stress disorder in migraine: further comments. Headache 49:787

    PubMed  Google Scholar 

  • Rhode AM, Hosing VG, Happe S, Biehl K, Young P, Evers S (2007) Comorbidity of migraine and restless legs syndrome–a case-control study. Cephalalgia 27:1255–1260

    PubMed  CAS  Google Scholar 

  • Rose KM, Carson AP, Sanford CP, Stang PE, Brown CA, Folsom AR, Szklo M (2004) Migraine and other headaches: associations with Rose angina and coronary heart disease. Neurology 63:2233–2239

    PubMed  CAS  Google Scholar 

  • Rose KM, Wong TY, Carson AP, Couper DJ, Klein R, Sharrett AR (2007) Migraine and retinal microvascular abnormalities: the atherosclerosis risk in communities study. Neurology 68:1694–1700

    PubMed  CAS  Google Scholar 

  • Rundek T, Elkind MS, Di Tullio MR, Carrera E, Jin Z, Sacco RL, Homma S (2008) Patent foramen ovale and migraine: a cross-sectional study from the Northern Manhattan Study (NOMAS). Circulation 118:1419–1424

    PubMed  Google Scholar 

  • Sakai F, Meyer JS (1979) Abnormal cerebrovascular reactivity in patients with migraine and cluster headache. Headache 19:257–266

    PubMed  CAS  Google Scholar 

  • Scher AI, Stewart WF, Ricci JA, Lipton RB (2003) Factors associated with the onset and remission of chronic daily headache in a population-based study. Pain 106:81–89

    PubMed  CAS  Google Scholar 

  • Scher AI, Bigal ME, Lipton RB (2005a) Comorbidity of migraine. Curr Opin Neurol 18:305–310

    PubMed  Google Scholar 

  • Scher AI, Terwindt GM, Picavet HS, Verschuren WM, Ferrari MD, Launer LJ (2005b) Cardiovascular risk factors and migraine: the GEM population-based study. Neurology 64:614–620

    PubMed  CAS  Google Scholar 

  • Scher AI, Stewart WF, Lipton RB (2006) The comorbidity of headache with other pain syndromes. Headache 46:1416–1423

    PubMed  Google Scholar 

  • Schur EA, Noonan C, Buchwald D, Goldberg J, Afari N (2009) A twin study of depression and migraine: evidence for a shared genetic vulnerability. Headache 49:1493–1502

    PubMed  Google Scholar 

  • Schürks M, Zee RY, Buring JE, Kurth T (2008) Interrelationships among the MTHFR 677C>T polymorphism, migraine, and cardiovascular disease. Neurology 71:505–513

    PubMed  Google Scholar 

  • Schürks M, Berger K, Glynn RJ, Buring JE, Kurth T (2009a) Association between migraine and restless legs syndrome in women. Neurology 72:A182

    Google Scholar 

  • Schürks M, Rist PM, Bigal ME, Buring JE, Lipton RB, Kurth T (2009b) Migraine and cardiovascular disease: a systematic review and meta-analysis. BMJ 339:b3914. doi:10.1136/bmj.b3914

    PubMed  Google Scholar 

  • Schürks M, Zee RYL, Buring JE, Kurth T (2009c) ACE D/I Polymorphism, migraine, and cardiovascular disease in women. Neurology 72:650–656

    PubMed  Google Scholar 

  • Schürks M, Rist PM, Kurth T (2010) MTHFR 677C>T and ACE D/I polymorphisms in migraine: a systematic review and meta-analysis. Headache 50:588–599

    PubMed  Google Scholar 

  • Schwaiger J, Kiechl S, Stockner H, Knoflach M, Werner P, Rungger G, Gasperi A, Willeit J (2008) Burden of atherosclerosis and risk of venous thromboembolism in patients with migraine. Neurology 71:937–943

    PubMed  CAS  Google Scholar 

  • Schwedt TJ, Demaerschalk BM, Dodick DW (2008) Patent foramen ovale and migraine: a quantitative systematic review. Cephalalgia 28:531–540

    PubMed  CAS  Google Scholar 

  • Seligman MEP (1975) Helplessness: on depression, development, and death. W.H. Freeman, San Francisco

    Google Scholar 

  • Sheftell FD, Tepper SJ, Lay CL, Bigal ME (2007) Post-traumatic headache: emphasis on chronic types following mild closed head injury. Neurol Sci 28(Suppl 2):S203–S207

    PubMed  Google Scholar 

  • Silvestrini M, Baruffaldi R, Bartolini M, Vernieri F, Lanciotti C, Matteis M, Troisi E, Provinciali L (2004) Basilar and middle cerebral artery reactivity in patients with migraine. Headache 44:29–34

    PubMed  Google Scholar 

  • Smitherman TA, Maizels M, Penzien DB (2008a) Headache chronification: screening and behavioral management of comorbid depressive and anxiety disorders. Headache 48:45–50

    PubMed  Google Scholar 

  • Smitherman TA, Penzien DB, Maizels M (2008b) Anxiety disorders and migraine intractability and progression. Curr Pain Headache Rep 12:224–229

    PubMed  Google Scholar 

  • Smoller JW, Pollack MH, Wassertheil-Smoller S, Barton B, Hendrix SL, Jackson RD, Dicken T, Oberman A, Sheps DS, Women's Health Initiative I (2003) Prevalence and correlates of panic attacks in postmenopausal women: results from an ancillary study to the women’s health initiative. Arch Intern Med 163:2041–2050

    PubMed  Google Scholar 

  • Sternfeld B, Stang P, Sidney S (1995) Relationship of migraine headaches to experience of chest pain and subsequent risk for myocardial infarction. Neurology 45:2135–2142

    PubMed  CAS  Google Scholar 

  • Stewart WF, Linet MS, Celentano DD (1989) Migraine headaches and panic attacks. Psychosom Med 51:559–569

    PubMed  CAS  Google Scholar 

  • Stewart W, Breslau N, Keck PE Jr (1994) Comorbidity of migraine and panic disorder. Neurology 44:S23–S27

    PubMed  CAS  Google Scholar 

  • Tietjen GE, Al-Qasmi MM, Shukairy MS (2002a) Livedo reticularis and migraine: a marker for stroke risk? Headache 42:352–355

    PubMed  Google Scholar 

  • Tietjen GE, Gottwald L, Al-Qasmi MM, Gunda P, Khuder SA (2002b) Migraine is associated with livedo reticularis: a prospective study. Headache 42:263–267

    PubMed  Google Scholar 

  • Tietjen GE, Al-Qasmi MM, Gunda P, Herial NA (2006) Sneddon's syndrome: another migraine-stroke association? Cephalalgia 26:225–232

    PubMed  CAS  Google Scholar 

  • Tietjen GE, Al-Qasmi MM, Athanas K, Utley C, Herial NA (2007a) Altered hemostasis in migraineurs studied with a dynamic flow system. Thromb Res 119:217–222

    PubMed  CAS  Google Scholar 

  • Tietjen GE, Brandes JL, Digre KB, Baggaley S, Martin V, Recober A, Geweke LO, Hafeez F, Aurora SK, Herial NA, Utley C, Khuder SA (2007b) High prevalence of somatic symptoms and depression in women with disabling chronic headache. Neurology 68:134–140

    PubMed  CAS  Google Scholar 

  • Tietjen GE, Brandes JL, Peterlin BL, Eloff A, Dafer RM, Stein MR, Drexler E, Martin VT, Hutchinson S, Aurora SK, Recober A, Herial NA, Utley C, White L, Khuder SA (2009a) Allodynia in migraine: association with comorbid pain conditions. Headache 49:1333–1344

    PubMed  Google Scholar 

  • Tietjen GE, Herial NA, White L, Utley C, Kosmyna JM, Khuder SA (2009b) Migraine and biomarkers of endothelial activation in young women. Stroke 40:2977–2982

    PubMed  CAS  Google Scholar 

  • Tietjen GE, Brandes JL, Peterlin BL, Eloff A, Dafer RM, Stein MR, Drexler E, Martin VT, Hutchinson S, Aurora SK, Recober A, Herial NA, Utley C, White L, Khuder SA (2010a) Childhood maltreatment and migraine (Part I). Prevalence and adult revictimization: a multicenter headache clinic survey. Headache 50:20–31

    PubMed  Google Scholar 

  • Tietjen GE, Brandes JL, Peterlin BL, Eloff A, Dafer RM, Stein MR, Drexler E, Martin VT, Hutchinson S, Aurora SK, Recober A, Herial NA, Utley C, White L, Khuder SA (2010b) Childhood maltreatment and migraine (Part II). Emotional abuse as a risk factor for headache chronification. Headache 50:32–41

    PubMed  Google Scholar 

  • Tietjen GE, Brandes JL, Peterlin BL, Eloff A, Dafer RM, Stein MR, Drexler E, Martin VT, Hutchinson S, Aurora SK, Recober A, Herial NA, Utley C, White L, Khuder SA (2010c) Childhood maltreatment and migraine (Part III). Association with comorbid pain conditions. Headache 50:42–51

    PubMed  Google Scholar 

  • Toldo I, Perissinotto E, Menegazzo F, Boniver C, Sartori S, Salviati L, Clementi M, Montagna P, Battistella PA (2010) Comorbidity between headache and epilepsy in a pediatric headache center. J Headache Pain 11(3):235–240

    PubMed  Google Scholar 

  • Totaro R, Marini C, De Matteis G, Di Napoli M, Carolei A (1997) Cerebrovascular reactivity in migraine during headache-free intervals. Cephalalgia 17:191–194

    PubMed  CAS  Google Scholar 

  • Tzourio C, Tehindrazanarivelo A, Iglesias S, Alperovitch A, Chedru F, d’Anglejan-Chatillon J, Bousser MG (1995) Case-control study of migraine and risk of ischaemic stroke in young women. BMJ 310:830–833

    PubMed  CAS  Google Scholar 

  • Vanmolkot FH, de Hoon JN (2007) Increased C-reactive protein in young adult patients with migraine. Cephalalgia 27:843–846

    PubMed  CAS  Google Scholar 

  • Vanmolkot FH, Van Bortel LM, de Hoon JN (2007) Altered arterial function in migraine of recent onset. Neurology 68:1563–1570

    PubMed  Google Scholar 

  • Velentgas P, Cole JA, Mo J, Sikes CR, Walker AM (2004) Severe vascular events in migraine patients. Headache 44:642–651

    PubMed  Google Scholar 

  • Von Korff M, Crane P, Lane M, Miglioretti DL, Simon G, Saunders K, Stang P, Brandenburg N, Kessler R (2005) Chronic spinal pain and physical-mental comorbidity in the United States: results from the national comorbidity survey replication. Pain 113:331–339

    Google Scholar 

  • Wang SJ, Fuh JL, Lu SR, Juang KD (2001) Quality of life differs among headache diagnoses: analysis of SF-36 survey in 901 headache patients. Pain 89:285–292

    PubMed  CAS  Google Scholar 

  • Wang SJ, Juang KD, Fuh JL, Lu SR (2007) Psychiatric comorbidity and suicide risk in adolescents with chronic daily headache. Neurology 68:1468–1473

    PubMed  Google Scholar 

  • Wang SJ, Fuh JL, Juang KD, Lu SR (2009) Migraine and suicidal ideation in adolescents aged 13 to 15 years. Neurology 72:1146–1152

    PubMed  Google Scholar 

  • Welch KM, Brandes AW, Salerno L, Brandes JL (2006) C-reactive protein may be increased in migraine patients who present with complex clinical features. Headache 46:197–199

    PubMed  CAS  Google Scholar 

  • Winter AC, Berger K, Buring JE, Kurth T (2009) Body mass index, migraine, migraine frequency and migraine features in women. Cephalalgia 29:269–278

    PubMed  CAS  Google Scholar 

  • Younes RP, DeLong GR, Neiman G, Rosner B (1986) Manic-depressive illness in children: treatment with lithium carbonate. J Child Neurol 1:364–368

    PubMed  CAS  Google Scholar 

  • Zintzaras E, Raman G, Kitsios G, Lau J (2008) Angiotensin-converting enzyme insertion/deletion gene polymorphic variant as a marker of coronary artery disease: a meta-analysis. Arch Intern Med 168:1077–1089

    PubMed  Google Scholar 

  • Zwart JA, Dyb G, Hagen K, Odegard KJ, Dahl AA, Bovim G, Stovner LJ (2003) Depression and anxiety disorders associated with headache frequency. The Nord-Trondelag Health Study. Eur J Neurol 10:147–152

    PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Preventive Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, 900 Commonwealth Avenue East, 3rd fl, Boston, MA, 02215-1204, USA

    Dr. Markus Schürks

  2. Department of Neurology, University Hospital Essen, Essen, Germany

    Dr. Markus Schürks

  3. Department of Neurology, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, 10461, USA

    Dr. Dawn C. Buse

  4. Ferkauf Graduate School of Psychology of Yeshiva University, Montefiore Headache Center, 1575 Blondell Avenue, Suite 225, Bronx, NY, 10461, USA

    Dr. Dawn C. Buse

  5. Department of Neurology, Neurological Institute, Taipei Veterans General Hospital, 201, Section 2, Shih-Pai Road, 112, Taipei, Taiwan

    Dr. Shuu-Jiun Wang

  6. Department of Neurology, National Yang-Ming University School of Medicine, Taipei, Taiwan

    Dr. Shuu-Jiun Wang

Authors
  1. Dr. Markus Schürks
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  2. Dr. Dawn C. Buse
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  3. Dr. Shuu-Jiun Wang
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Corresponding author

Correspondence to Markus Schürks .

Editor information

Editors and Affiliations

  1. Department of Medical and Molecular Sciences, School of Health Sciences, Sapienza University of Rome, Rome, Italy

    Paolo Martelletti

  2. Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway

    Timothy J. Steiner

  3. Department of Neuroscience, Faculty of Medicine, Imperial College London, London, UK

    Timothy J. Steiner

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© 2011 Lifting The Burden

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Schürks, M., Buse, D.C., Wang, SJ. (2011). Comorbidities of Headache Disorders. In: Martelletti, P., Steiner, T.J. (eds) Handbook of Headache. Springer, Milano. https://doi.org/10.1007/978-88-470-1700-9_10

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  • DOI: https://doi.org/10.1007/978-88-470-1700-9_10

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-1699-6

  • Online ISBN: 978-88-470-1700-9

  • eBook Packages: MedicineReference Module Medicine

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