Sympathetic Ophthalmia

  • Kanika Aggarwal
  • Aniruddha Agarwal
  • Ramanuj Samanta
  • Mohit Dogra
  • Pallavi Singh
  • Vishali Gupta
Living reference work entry


Sympathetic ophthalmia is a potentially sight-threatening condition characterized by bilateral inflammation of the entire uveal tract that follows a perforating wound or surgical insult to one eye and has an insidious or acute onset and progressive course with recurrences. The clinical presentation is variable with some patients showing only posterior segment manifestations at initial presentation. Yellowish-white sub-RPE nodular lesions corresponding to histopathologic Dalen-Fuchs nodules are typical although not pathognomic of this condition. Long-term treatment with corticosteroids and immunomodulatory drugs is the mainstay of therapy.


Mycophenolate Mofetil Sympathetic Ophthalmia Multifocal Choroiditis Pigment Epitheliopathy Uveal Effusion 
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Suggested Reading

  1. Albert DM, Rohena R. A historical review of sympathetic ophthalmia and its epidemiology. Surv Ophthalmol. 1989;34:1–14.CrossRefPubMedGoogle Scholar
  2. Gupta V, Gupta A, Dogra MR. Posterior sympathetic ophthalmia: a single centre long-term study of 40 patients from North India. Eye. 2008;22(12):1459–64.CrossRefPubMedGoogle Scholar
  3. Gupta V, Gupta A, Dogra MR, Singh I. Reversible retinal changes in the acute stage of sympathetic ophthalmia seen on spectral domain optical coherence tomography. Int Ophthalmol. 2011;2:105–10.CrossRefGoogle Scholar
  4. Kumar K, Mathai A, Murthy SI, Jalali S, Sangwan V, Reddy Pappuru R, Pathangay A. Sympathetic ophthalmia in pediatric age group: clinical features and challenges in management in a tertiary center in Southern India. Ocul Immunol Inflamm. 2014;22(5):367–72.Google Scholar
  5. Ozbek Z, Arikan G, Yaman A, Oner H, Bajin MS, Saatci AO. Sympathetic ophthalmia following vitreoretinal surgery. Int Ophthalmol. 2010;30(2):221–7.Google Scholar

Copyright information

© Springer India 2016

Authors and Affiliations

  1. 1.Advanced Eye CenterPost Graduate Institute of Medical Education and ResearchChandigarhIndia

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