While sarcoidosis most frequently affects the lungs, this disease that can have protean manifestations may involve numerous other organs. Ocular involvement can be seen in up to 50% of cases of sarcoidosis and may be the initial presentation of the disease. While it is true that sarcoidosis is characterized by noncaseating granulomas obtained from an involved organ, clinical and laboratory features and radiographic imaging are often combined to support a diagnosis of sarcoidosis. For example, berylliosis is also associated with the formation of noncaseating granulomas. Tuberculosis and syphilis should be excluded as a possibility as these can masquerade as ocular sarcoidosis. Thus, a thorough review of a patient’s past medical history, review of systems, and social history play important roles in the evaluation of ocular sarcoidosis.
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