Behçet’s Uveitis

  • Ilknur Tugal-Tutkun
Living reference work entry


Behçet’s uveitis is one of the most severe forms of intraocular inflammation involving both anterior and posterior segments of the eye. Nongranulomatous anterior uveitis, diffuse vitritis, and leaky and occlusive retinal vasculitis are the characteristic features. A variety of acute inflammatory signs of variable severity appear at the onset of uveitis attacks, including anterior chamber cells and flare, hypopyon, diffuse vitreous cells and haze, retinal infiltrates, hemorrhages, edema, sheathing and occlusion of retinal vasculature, predominantly retinal veins of any size, and papillitis. High-dose corticosteroids combined with conventional immunomodulatory agents are generally used as the first-line treatment; biologic agents such as interferon alpha and TNF inhibitors are used in refractory cases in order to control acute intraocular inflammation and to prevent recurrences in this potentially blinding disease.


Retinal Nerve Fiber Layer Retinal Vein Occlusion Cystoid Macular Edema Branch Retinal Vein Occlusion Retinal Vasculitis 
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Suggested Reading

  1. Tugal-Tutkun I. Behçet’s uveitis. Middle East Afr J Ophthalmol. 2009;16:219–24.PubMedPubMedCentralGoogle Scholar
  2. Tugal-Tutkun I. Imaging in the diagnosis and management of Behçet disease. Int Ophthalmol Clin. 2012;52:183–90.CrossRefPubMedGoogle Scholar
  3. Tugal-Tutkun I, Onal S, Altan-Yaycioglu R, Altunbas HH, Urgancioglu M. Uveitis in Behçet disease: an analysis of 880 patients. Am J Ophthalmol. 2004;138:373–80.CrossRefPubMedGoogle Scholar
  4. Tugal-Tutkun I, Gupta V, Cunningham ET. Differential Diagnosis of Behçet Uveitis. Ocul Immunol Inflamm. 2013;21:337–50.CrossRefPubMedGoogle Scholar
  5. Zierhut M, Abu El-Asrar AM, Bodaghi B, Tugal-Tutkun I. Therapy of ocular Behçet disease. Ocul Immunol Inflamm. 2014;22:64–76.CrossRefPubMedGoogle Scholar

Copyright information

© Springer India 2016

Authors and Affiliations

  1. 1.Department of Ophthalmology, Istanbul faculty of MedicineIstanbul UniversityIstanbulTurkey

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