Subacute Sclerosing Panencephalitis

Living reference work entry


Subacute sclerosing panencephalitis (SSPE) is a rare neurodegenerative disease caused by a defective measles virus. About 1 in 10,000 patients of measles develops SSPE after a latent period of 5–15 years. It is characterized by progressive psychoneuronal changes, myoclonic seizures, dementia, ocular changes, coma, and eventually death. Ocular changes include necrotizing macular retinitis, optic neuritis, cortical blindness, hemianopia, and extraocular muscle paresis.


Optic Neuritis Retinal Hemorrhage Spontaneous Remission Retinal Tissue Amplitude Spike 
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Suggested Reading

  1. Babu RB, Biswas J. Bilateral macular retinitis as a presenting feature of SSPE. J Neuroophthalmol. 2007;27(4):288–91.CrossRefPubMedGoogle Scholar
  2. Cochereau Massin I, et al. Changes in the fundus in SSPE: apropos of 23 cases. J Fr Ophtalmol. 1992;15(4):255–61.PubMedGoogle Scholar
  3. Sardaroglu A, et al. Macular retinitis as a first sign of SSPE: importance of early diagnosis. Ocul Immunol Infllamm. 2005;13(5):405–10.CrossRefGoogle Scholar

Copyright information

© Springer India 2016

Authors and Affiliations

  1. 1.Advanced Eye CenterPost Graduate Institute of Medical Education and ResearchChandigarhIndia

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