Posterior Segment Manifestations of Leptospirosis

  • Sudheer Bhagya
  • S. R. Rathinam
Living reference work entry


Leptospirosis is a zoonotic water borne illness in tropical countries caused by a spirochete of genus Leptospira . It presents in the initial phase as an acute febrile illness followed by an asymptomatic latent period, and uveitis is a late complication of leptospirosis. The incidence being 10–45%. The most common anatomical location is either anterior or panuveitis. Leptospirosis frequently presents as a nongranulomatous anterior uveitis. It is one of the important causes of hypopyon uveitis in leptospiral endemic areas. Early onset, rapid progression, and spontaneous absorption of cataractous lens is a unique feature in this uveitis; however, it is seen only in 10% of leptospiral uveitis. Dense vitreous inflammation with the formation of veil-like membranes is commonly seen in posterior segment. Exudative retinal vasculitis with perivascular sheathing of the vein is frequently seen in leptospiral uveitis, although occlusion and neovascularisation are uncommon. Disc hyperemia and edema can also be seen.


Anterior Uveitis Purify Protein Derivative Retinal Vasculitis High Grade Fever Acute Febrile Illness 
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Suggested Reading

  1. Durski KN, Jancloes M, Chowdhary T, Bertherat E. A global, multi-disciplinary, multi-sectorial initiative to combat leptospirosis: Global Leptospirosis Environmental Action Network (GLEAN). Int J Environ Res Public Health. 2014;11:6000–8.CrossRefPubMedPubMedCentralGoogle Scholar
  2. Rathinam SR. Ocular leptospirosis. Curr Opin Ophthalmol. 2002;13:381–6.CrossRefPubMedGoogle Scholar
  3. Rathinam SR, Rathnam S, Selvaraj S, Dean D, Nozik RA, Namperumalsamy P. Uveitis associated with an epidemic outbreak of leptospirosis. Am J Ophthalmol. 1997;124:71–9.CrossRefPubMedGoogle Scholar
  4. Rathinam SR, Namperumalsamy P, Cunningham ET. Spontaneous cataract absorption in patients with leptospiral uveitis. Br J Ophthalmol. 2000;84:1135–41.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer India 2016

Authors and Affiliations

  1. 1.Uvea ServicesAravind Eye HospitalMaduraiIndia
  2. 2.Department of OphthalmologyAravind Eye Hospital and PG Institute OphthalmologyMaduraiIndia

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