Fucosyltransferase 4. GDP-Fucose Lactosamine α1,3-Fucosyltransferase. Myeloid Specific (FUT4)

  • Takashi Kudo
  • Hisashi Narimatsu
Reference work entry


α1,3-Fucosyltransferase-IV (FUT4, Fuc-TIV) was cloned independently by two groups at almost the same time (Goelz et al. 1990; Lowe et al. 1991). It was first cloned as an α1,3-fucosyltransferase determining the expression of the ligand for the endothelial leukocyte adhesion molecule-1 (ELAM-1) by Goelz et al. and named ELAM-1 ligand fucosyltransferase (ELFT). Lowe et al. cloned it by cross-hybridization with a probe of FUT3 cDNA. However, the terms ELAM-1 and ELFT are not used currently; they have been renamed E-selection and FUT4, respectively. The Fut4 gene is one of three active Fut genes, Fut4, Fut7, and Fut9, in rodents and has been cloned from several species. FUT4 expressed in many tissues (Gersten et al. 1995; Kaneko et al. 1999).


Peripheral Lymph Node High Endothelial Venule Human Promyelocytic Leukemia Cell Namalwa Cell Human FUT4 
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Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.University of TsukubaTsukubaJapan
  2. 2.Research Center for Medical GlycoscienceNational Institute of Advanced Industrial Science and Technology (AIST)TsukubaJapan

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