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Fucosyltransferase 3. GDP-Fucose Lactosamine α1,3/4-Fucosyltransferase. Lea and Leb Histo-Blood Groups (FUT3, Lewis Enzyme)

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Handbook of Glycosyltransferases and Related Genes

Abstract

α1,3/4-Fucosyltransferase was cloned firstly among the members of the α1,3-fucosyltransferase (α1,3FUT) family (Kukowska-Latallo et al. 1990) and named Fuc-TIII by J. Lowe et al. or FUT3 by Oriol et al. Later FUT3 (Fuc-TIII) was demonstrated to be the Lewis enzyme that determines the expression of Lewis histo-blood group antigens, i.e., Lewis a (Lea) and b (Leb) (Mollicone et al. 1994; Nishihara et al. 1994). FUT3 catalyzes transfer of fucose from GDP-fucose to the GlcNAc residue of type-2 chain, Galb1-4GlcNAc, with an α1,3-linkage, or to the GlcNAc residue of type-1 chain, Galb1-3GlcNAc, with an α1,4-linkage. The biosynthetic pathways of Lewis antigen epitopes in relation to ABH antigens are summarized in Fig. 48.1.

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Authors and Affiliations

  1. University of Tsukuba, Tsukuba, Japan

    Dr. Takashi Kudo

  2. Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan

    Hisashi Narimatsu

Authors
  1. Dr. Takashi Kudo
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  2. Hisashi Narimatsu
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Corresponding author

Correspondence to Takashi Kudo .

Editor information

Editors and Affiliations

  1. RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN, Wako, Saitama, Japan

    Naoyuki Taniguchi

  2. Department of Biochemistry, Kochi University, Medical School, Nankoku, Kochi, Japan

    Koichi Honke

  3. Sanford Burnham Medical Research Institute, La Jolla, California, USA

    Minoru Fukuda

  4. Research Center for Medical Glycoscience (RCMG), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan

    Hisashi Narimatsu

  5. RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN, Wako, Saitama, Japan

    Yoshiki Yamaguchi

  6. Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan

    Takashi Angata

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© 2014 Springer Japan

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Kudo, T., Narimatsu, H. (2014). Fucosyltransferase 3. GDP-Fucose Lactosamine α1,3/4-Fucosyltransferase. Lea and Leb Histo-Blood Groups (FUT3, Lewis Enzyme). In: Taniguchi, N., Honke, K., Fukuda, M., Narimatsu, H., Yamaguchi, Y., Angata, T. (eds) Handbook of Glycosyltransferases and Related Genes. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54240-7_94

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