Fucosyltransferase 3. GDP-Fucose Lactosamine α1,3/4-Fucosyltransferase. Lea and Leb Histo-Blood Groups (FUT3, Lewis Enzyme)

  • Takashi Kudo
  • Hisashi Narimatsu
Reference work entry


α1,3/4-Fucosyltransferase was cloned firstly among the members of the α1,3-fucosyltransferase (α1,3FUT) family (Kukowska-Latallo et al. 1990) and named Fuc-TIII by J. Lowe et al. or FUT3 by Oriol et al. Later FUT3 (Fuc-TIII) was demonstrated to be the Lewis enzyme that determines the expression of Lewis histo-blood group antigens, i.e., Lewis a (Lea) and b (Leb) (Mollicone et al. 1994; Nishihara et al. 1994). FUT3 catalyzes transfer of fucose from GDP-fucose to the GlcNAc residue of type-2 chain, Galb1-4GlcNAc, with an α1,3-linkage, or to the GlcNAc residue of type-1 chain, Galb1-3GlcNAc, with an α1,4-linkage. The biosynthetic pathways of Lewis antigen epitopes in relation to ABH antigens are summarized in Fig. 48.1.


GlcNAc Residue Lewis Antigen A431 Epidermoid Carcinoma Cell Epidermoid Carcinoma Cell Line Human FUT3 
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Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.University of TsukubaTsukubaJapan
  2. 2.Research Center for Medical GlycoscienceNational Institute of Advanced Industrial Science and Technology (AIST)TsukubaJapan

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