Abstract
β1,3-N-Acetylglucosaminyltransferases (β3GnTs) synthesize a unique carbohydrate structure known as polylactosamine (poly-N-acetyllactosamine). Polylactosamines are carried on N-glycan, O-glycans, and glycolipids. The polylactosamine unit is considered an integral component that serves as a fundamental structure and backbone for carbohydrates.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Castronovo V, Luyten F, van den Brule F, Sobel ME (1992) Identification of a 14-kDa laminin binding protein (HLBP14) in human melanoma cells that is identical to the 14-kDa galactoside binding lectin. Arch Biochem Biophys 297:132–138
Dennis JW, Carver JP, Schachter H (1984) Asparagine-linked oligosaccharides in murine tumor cells: comparison of a WGA-resistant (WGAr) nonmetastatic mutant and a related WGA-sensitive (WGAs) metastatic line. J Cell Biol 99:1034–1044
Dennis JW, Laferte S, Vanderelst I (1989) Asparagine-linked oligosaccharides in malignant tumour growth. Biochem Soc Trans 17:29–31
Gastinel LN, Cambillau C, Bourne Y (1999) Crystal structures of the bovine beta 4 galactosyltransferase catalytic domain and its complex with uridine diphosphogalactose. EMBO J 18:3546–3557
Granovsky M, Fata J, Pawling J, Muller WJ, Khokha R, Dennis JW (2000) Suppression of tumor growth and metastasis in Mgat5-deficient mice. Nat Med 6:306–312
Hua D, Qin F, Shen L, Jiang Z, Zou ST, Xu L, Cheng ZH, Wu SL (2012) beta3GnT8 regulates laryngeal carcinoma cell proliferation via targeting MMPs/TIMPs and TGF-beta1. Asian Pacific J Cancer Prev: APJCP 13:2087–2093
Huang C, Zhou J, Wu S, Shan Y, Teng S, Yu L (2004) Cloning and tissue distribution of the human B3GALT7 gene, a member of the beta1,3-Glycosyltransferase family. Glycoconj J 21:267–273
Ishida H, Togayachi A, Sakai T, Iwai T, Hiruma T, Sato T, Okubo R, Inaba N, Kudo T, Gotoh M, Shoda J, Tanaka N, Narimatsu H (2005) A novel beta1,3-N-acetylglucosaminyltransferase (beta3Gn-T8), which synthesizes poly-N-acetyllactosamine, is dramatically upregulated in colon cancer. FEBS Lett 579:71–78
Ohyama C, Tsuboi S, Fukuda M (1999) Dual roles of sialyl Lewis X oligosaccharides in tumor metastasis and rejection by natural killer cells. EMBO J 18:1516–1525
Pierce M, Buckhaults P, Chen L, Fregien N (1997) Regulation of N-acetylglucosaminyltransferase V and Asn-linked oligosaccharide beta(1,6) branching by a growth factor signaling pathway and effects on cell adhesion and metastatic potential. Glycoconj J 14:623–630
Saitoh O, Wang WC, Lotan R, Fukuda M (1992) Differential glycosylation and cell surface expression of lysosomal membrane glycoproteins in sublines of a human colon cancer exhibiting distinct metastatic potentials. J Biol Chem 267:5700–5711
Seberger PJ, Chaney WG (1999) Control of metastasis by Asn-linked, beta1-6 branched oligosaccharides in mouse mammary cancer cells. Glycobiology 9:235–241
Seko A, Yamashita K (2005) Characterization of a novel galactose: {beta}1,3-N-acetylglucosaminyltransferase ({beta}3Gn-T8): the complex formation of {beta}3Gn-T2 and {beta}3Gn-T8 enhances enzymatic activity. Glycobiology 15:943–951
Seko A, Yamashita K (2008) Activation of beta1,3-N-acetylglucosaminyltransferase-2 (beta3Gn-T2) by beta3Gn-T8. Possible involvement of beta3Gn-T8 in increasing poly-N-acetyllactosamine chains in differentiated HL-60 cells. J Biol Chem 283:33094–33100
Shen L, Liu Z, Tu Y, Xu L, Sun X, Wu S (2011) Regulation of MMP-2 expression and activity by beta-1,3-N-acetylglucosaminyltransferase-8 in AGS gastric cancer cells. Mol Biol Rep 38:1541–1550
Togayachi A, Sato T, Narimatsu H (2006) Comprehensive enzymatic characterization of glycosyltransferases with a beta3GT or beta4GT motif. Methods Enzymol 416:91–102
Ujita M, McAuliffe J, Hindsgaul O, Sasaki K, Fukuda MN, Fukuda M (1999) Poly-N-acetyllactosamine synthesis in branched N-glycans is controlled by complemental branch specificity of I-extension enzyme and beta1,4-galactosyltransferase I. J Biol Chem 274:16717–16726
Zhang Z, Zhao Y, Jiang L, Miao X, Zhou H, Jia L (2012) Glycomic alterations are associated with multidrug resistance in human leukemia. Int J Biochem Cell Biol 44:1244–1253
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer Japan
About this entry
Cite this entry
Togayachi, A., Narimatsu, H. (2014). UDP-GlcNAc: BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 8 (B3GNT8). In: Taniguchi, N., Honke, K., Fukuda, M., Narimatsu, H., Yamaguchi, Y., Angata, T. (eds) Handbook of Glycosyltransferases and Related Genes. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54240-7_93
Download citation
DOI: https://doi.org/10.1007/978-4-431-54240-7_93
Published:
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-54239-1
Online ISBN: 978-4-431-54240-7
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences