UDP-GlcNAc: BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 4 (B3GNT4)

Reference work entry


β1,3-N-Acetylglucosaminyltransferase (β3GnT) enzymes synthesize a unique carbohydrate structure known as polylactosamine (poly-N-acetyllactosamine). Polylactosamines are carried on N- and O-glycans and glycolipids. Polylactosamine units are considered as integral components serving as a fundamental structure and backbone for carbohydrate assemblies (Fig. 28.1).


Fundamental Structure Pulse Amperometric Detection Carbohydrate Assembly Transmembrane Topology Tomato Lectin 
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  1. Shiraishi N, Natsume A, Togayachi A, Endo T, Akashima T, Yamada Y, Imai N, Nakagawa S, Koizumi S, Sekine S, Narimatsu H, Sasaki K (2001) Identification and characterization of three novel β1,3-N-acetylglucosaminyltransferases structurally related to the β1,3-galactosyltransferase family. J Biol Chem 276:3498–3507PubMedCrossRefGoogle Scholar
  2. Togayachi A, Akashima T, Ookubo R, Kudo T, Nishihara S, Iwasaki H, Natsume A, Mio H, Inokuchi J, Irimura T, Sasaki K, Narimatsu H (2001) Molecular cloning and characterization of UDP-GlcNAc:lactosylceramide β1,3-N-acetylglucosaminyltransferase (β3Gn-T5), an essential enzyme for the expression of HNK-1 and Lewis X epitopes on glycolipids. J Biol Chem 276:22032–22040PubMedCrossRefGoogle Scholar
  3. Zhou D, Dinter A, Gutierrez Gallego R, Kamerling JP, Vliegenthart JF, Berger EG, Hennet T (1999) A β-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to beta-1,3-galactosyltransferases. Proc Natl Acad Sci USA 96:406–411PubMedCrossRefGoogle Scholar

Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)TsukubaJapan

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