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UDP-GlcNAc: BetaGal Beta-1,3-N-Acetylglucosaminyltransferase 2 (B3GNT2)

  • Akira Togayachi
  • Hisashi Narimatsu
Reference work entry

Abstract

β1,3-N-acetylglucosaminyltransferase 2 (β3GnT2) synthesizes a unique carbohydrate structure known as polylactosamine (poly-N-acetyllactosamine). Polylactosamines are carried on N- and O-glycans and glycolipids. Polylactosamine-containing repeats of the N-acetyllactosamine (LacNAc) unit (Gal[galactose]β1-4GlcNAc[N-acetylglucosamine] β1-3)n represent a fundamental structure of glycans carried on N- and O-glycans, as well as on glycosphingolipids (glycolipids). Polylactosamines are synthesized coordinately by the alternative action of a β1,4-galactosyltransferase (β4GalT) and a β1,3-N-acetylglucosaminyltransferase (β3GnT).

Keywords

HUGO Gene Nomenclature Committee Lymphocyte Homing Glycosyltransferase Gene Oligosaccharide Substrate Putative Catalytic Domain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST)TsukubaJapan

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