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Carbohydrate (N-Acetylglucosamine-6-O) Sulfotransferase 2 (CHST2)

  • Kenji Uchimura
Reference work entry

Abstract

The CHST2 gene encodes N-acetylglucosamine-6-O-sulfotransferase (GlcNAc6ST)-1. GlcNAc6ST-1 catalyzes the transfer of a sulfate group from the substrate 3′-phosphoadenosine 5-phosphosulfate (PAPS) to an N-acetylglucosamine residue located at the nonreducing end of glycans (Uchimura et al. 1998). GlcNAc6ST-1 has the configuration of type II transmembrane proteins. The enzyme is localized to the Golgi. GlcNAc6ST-1 is a member of the GlcNAc6ST family in that five isozymes of GlcNAc6STs have been identified in humans, four of which have murine orthologs (Uchimura and Rosen 2006). GlcNAc6ST-1 mRNA of human and mouse is expressed in a variety of tissues including brain, eye, lung, pancreas, and lymph nodes. GlcNAc6ST-1 elaborates sialyl 6-sulfo Lewis X (6-sulfo sLex), which is a major L-selectin ligand expressed in high endothelial venules (HEV) of lymph nodes, and regulates lymphocyte homing (Uchimura et al. 2004, 2005; Kawashima et al. 2005). GlcNAc6ST-1 is also an enzyme that synthesizes keratan sulfate (KS) glycosaminoglycan in the central nervous system and regulates axonal regeneration after injury (Zhang et al. 2006; Ito et al. 2010).

Keywords

Null Mouse Axonal Regeneration Keratan Sulfate High Endothelial Venule Corneal Dystrophy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.Department of BiochemistryNagoya University Graduate School of MedicineNagoyaJapan

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