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Exostosin 1,2 (EXT1,2)

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Handbook of Glycosyltransferases and Related Genes

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Abstract

Proteoglycans (PGs) that carry the heparan sulfate (HS) glycosaminoglycans (GAGs) are ubiquitously expressed on cell surfaces and in extracellular matrices, and these HS chains interact with numerous proteins including growth factors, morphogens, and extracellular matrix proteins. These interactions form the basis of HS-related biological phenomena. Thus, the biosynthesis of HS regulates key events in embryonic development and physiological homeostasis, and deranged HS biosynthesis can cause diseases.

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Authors and Affiliations

  1. Department of Biochemistry, Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, 658-8558, Higashinada-ku, Kobe, Japan

    Prof. Hiroshi Kitagawa & Dr. Satomi Nadanaka

Authors
  1. Prof. Hiroshi Kitagawa
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  2. Dr. Satomi Nadanaka
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Corresponding author

Correspondence to Hiroshi Kitagawa .

Editor information

Editors and Affiliations

  1. RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN, Wako, Saitama, Japan

    Naoyuki Taniguchi

  2. Department of Biochemistry, Kochi University, Medical School, Nankoku, Kochi, Japan

    Koichi Honke

  3. Sanford Burnham Medical Research Institute, La Jolla, California, USA

    Minoru Fukuda

  4. Research Center for Medical Glycoscience (RCMG), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan

    Hisashi Narimatsu

  5. RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN, Wako, Saitama, Japan

    Yoshiki Yamaguchi

  6. Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan

    Takashi Angata

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Kitagawa, H., Nadanaka, S. (2014). Exostosin 1,2 (EXT1,2). In: Taniguchi, N., Honke, K., Fukuda, M., Narimatsu, H., Yamaguchi, Y., Angata, T. (eds) Handbook of Glycosyltransferases and Related Genes. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54240-7_81

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