Fucosyltransferase 6. GDP-Fucose Lactosamine α3-Fucosyltransferase (FUT6)

  • Reiji Kannagi
Reference work entry


Fuc-T VI was cloned as a fourth member of human α1→3/4 fucosyltransferase gene family by Weston et al. in 1992. The enzyme shared 85 % or 89 % amino acid sequence identity with previously cloned Fuc-T III or Fuc-T V, respectively, and the FUT6 gene encoding the enzyme was shown to be located on chromosome 19, where the genes for Fuc-T III or Fuc-T V are also located. Fuc-T VI is able to synthesize Lewis x and sialyl Lewis x, but not sialyl Lewis a or Lewis a. The enzyme turned out to be the “plasma-type” fucosyltransferase and is known to synthesize the sialyl Lewis x determinant carried by plasma proteins and epithelial cancer cells.


Epithelial Cancer Cell Fucose Residue Fourth Member Chain Substrate Fucosyltransferase Activity 
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© Springer Japan 2014

Authors and Affiliations

  1. 1.Advanced Medical Research CenterAichi Medical UniversityNagakuteJapan

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