UDP-Xylose and UDP-N-Acetylglucosamine Transporter (SLC35B4)

Reference work entry


Nucleotide sugars that are synthesized in the cytoplasm or nucleus have to be transported over the membrane of the endoplasmic reticulum (ER) or Golgi to be used by glycosyltransferases in the lumen of the secretory pathway. There is one exception; UDP-xylose is made within the lumen of the ER or Golgi (Kearns et al. 1993; Hwang and Horvitz 2002; Moriarity et al. 2002; Bakker et al. 2009), suggesting there is no need for UDP-Xyl transport over the membrane. Still, transport of externally added UDP-Xyl over the Golgi membrane of mammalian cell has been observed (Nuwayhid et al. 1986; Milla et al. 1992; Kearns et al. 1993).


Nucleotide Sugar Golgi Membrane Golgi Vesicle SLC35 Family Hydrophilic Loop 
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Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.Institute for Cellular ChemistryHannover Medical SchoolHannoverGermany

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