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UDP-Xylose and UDP-N-Acetylglucosamine Transporter (SLC35B4)

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Handbook of Glycosyltransferases and Related Genes

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Abstract

Nucleotide sugars that are synthesized in the cytoplasm or nucleus have to be transported over the membrane of the endoplasmic reticulum (ER) or Golgi to be used by glycosyltransferases in the lumen of the secretory pathway. There is one exception; UDP-xylose is made within the lumen of the ER or Golgi (Kearns et al. 1993; Hwang and Horvitz 2002; Moriarity et al. 2002; Bakker et al. 2009), suggesting there is no need for UDP-Xyl transport over the membrane. Still, transport of externally added UDP-Xyl over the Golgi membrane of mammalian cell has been observed (Nuwayhid et al. 1986; Milla et al. 1992; Kearns et al. 1993).

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Authors and Affiliations

  1. Institute for Cellular Chemistry, Hannover Medical School, Build. J3, Level 4, Room 1290, Carl-Neubergstrasse 1, 30625, Hannover, Germany

    Dr. Hans Bakker & Dr. Angel Ashikov

Authors
  1. Dr. Hans Bakker
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  2. Dr. Angel Ashikov
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Corresponding author

Correspondence to Hans Bakker .

Editor information

Editors and Affiliations

  1. RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN, Wako, Saitama, Japan

    Naoyuki Taniguchi

  2. Department of Biochemistry, Kochi University, Medical School, Nankoku, Kochi, Japan

    Koichi Honke

  3. Sanford Burnham Medical Research Institute, La Jolla, California, USA

    Minoru Fukuda

  4. Research Center for Medical Glycoscience (RCMG), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan

    Hisashi Narimatsu

  5. RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN, Wako, Saitama, Japan

    Yoshiki Yamaguchi

  6. Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan

    Takashi Angata

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Bakker, H., Ashikov, A. (2014). UDP-Xylose and UDP-N-Acetylglucosamine Transporter (SLC35B4). In: Taniguchi, N., Honke, K., Fukuda, M., Narimatsu, H., Yamaguchi, Y., Angata, T. (eds) Handbook of Glycosyltransferases and Related Genes. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54240-7_8

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