ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 2 (ST8SIA2)

  • Chihiro Sato
Reference work entry


ST8 α-N-acetyl-neuraminide α-2,8-sialyltransferase 2 (ST8SIA2) is a member of a family of α2,8-sialyltransferases that transfer sialic acid from CMP-sialic acid onto sialic acid residues of other sialoglycans to generate α2,8-linked sialoglycans. ST8SIA2 is characterized by the ability to synthesize polysialic acid (polySia) structure and can therefore be subclassified as a polysialyltransferase. Both ST8SIA2 and the related polysialyltransferase ST8SIA4 (refer to the Chap. ST8SIA4) are capable of synthesizing extraordinary long polySia chains with degrees of polymerization (DP) of up to 400. ST8SIA2 is a type II transmembrane protein, similar to many other glycosyltransferases, and is composed of 375 amino acids with six N-glycans. This enzyme contains sialyl-motif (SM) L, S, VS, and III domains.


Sialic Acid Residue Acceptor Substrate Polysialic Acid Ocular Dominance Plasticity Medial Habenular Nucleus 
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© Springer Japan 2014

Authors and Affiliations

  1. 1.Bioscience and Biotechnology CenterNagoya UniversityNagoyaJapan

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