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ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 4 (ST3GAL4)

  • Ronald L. Schnaar
Reference work entry

Abstract

ST3Gal-IV is a member of the β-galactoside α-2,3-sialyltransferase family, transferring sialic acid in α2,3 linkage from CMP-NeuAc preferentially to Galβ1-4GlcNAc termini, but also to Galβ1-3GlcNAc and Galβ1-3GalNAc termini on glycoproteins and glycolipids. Included among its acceptors is Lex (Galβ1-4(Fucα1-3)GlcNAc) to produce sialyl Lex, a glycan determinant important in leukocyte trafficking.

Keywords

Sialic Acid Leukocyte Trafficking Asialoglycoprotein Receptor Selectin Ligand Glycan Determinant 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.Departments of Pharmacology and NeuroscienceJohns Hopkins University School of MedicineBaltimoreUSA

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