ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 3 (ST3GAL3)

  • Ronald L. Schnaar
Reference work entry


ST3Gal-III is a member of the N-acetyllactosaminide α-2,3-sialyltransferase family, transferring sialic acid from CMP-NeuAc in α-2,3 linkage preferentially to Galβ1-3GlcNAc, but also to Galβ1-4GlcNAc and Galβ1-3GalNAc termini on glycoproteins and glycolipids. It was among the first sialyltransferases purified and cloned (Wen et al. 1992), leading to the discovery of sialyltransferase sialyl motifs.


Sialic Acid Intellectual Disability Brain Ganglioside Sialic Acid Analog Disaccharide Acceptor 
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Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.Departments of Pharmacology and NeuroscienceJohns Hopkins University School of MedicineBaltimoreUSA

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