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Carbohydrate Sulfotransferase 10 (CHST10)

  • Hans Bakker
Reference work entry

Abstract

The sulfotransferase with the official gene name carbohydrate sulfoctransferase 10 (CHST10) is involved in the biosynthesis of the HNK-1 carbohydrate epitope, originally described as a differentiation antigen specifically expressed on human natural killer (HNK) cells (Abo and Balch 1981). Shortly after, it was discovered that the HNK-1 antibody detected cells and tumors of neuroectodermal origin in addition (Lipinski et al. 1983; Schuller-Petrovic et al. 1983) and that myelin-associated glycoprotein (MAG) was a target (McGarry et al. 1983). From then, research on the HNK-1 epitope focused on the nervous system. The antibody was shown to recognize both glycoproteins and glycolipids, defining HNK-1 as a carbohydrate epitope (Ilyas et al. 1984). An independently isolated antibody called L2 (or 412, L2-412, or HNK-1-412, here further called L2) detected the same carbohydrate epitope as HNK-1 on neural cell adhesion molecule (NCAM), MAG, and L1 (Kruse et al. 1984). Chou et al. (1986) then identified the glycolipid structure that was recognized by the antibody as SO4-3GlcAβ1-3Galβ1-4GlcNAcβ1-3Galβ1-4Glcβ1-Cer. On proteins, the structure has been found on both N-linked (Voshol et al. 1996; Liedtke et al. 2001; Wuhrer et al. 2003) and O-linked glycans. In O-glycans the structure has been identified on O-mannose (Yuen et al. 1997) and mucin-type, O-GalNAc-linked, glycans (Ong et al. 2002). The common structure on glycolipids and glycoproteins is SO4-3GlcAβ1-3Galβ1-4/3GlcNAc (Fig. 92.1). This sulfated trisaccharide is generally defined as the HNK-1 structure. The existence of at least one sulfotransferase transferring sulfate to the C3 position of glucuronic acid, tentatively called the HNK-1 sulfotransferase, could be predicted from this structure.

Keywords

Sialic Acid Glucuronic Acid Neural Cell Adhesion Molecule Carbohydrate Epitope Polysialic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.Institute for Cellular ChemistryHannover Medical SchoolHannoverGermany

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