Hyaluronan Synthase 1-3 (HAS1-3)

  • Naoki Itano
  • Theerawut Chanmee
  • Koji Kimata
Reference work entry


Hyaluronan (HA) is a major macromolecular polysaccharide component of the extracellular matrix that forms the structural framework of cells. It is composed of repeating GlcNAc ß (1→4)-GlcUAß(1→3) disaccharide units and has a molecular mass ranging from 103 to 107 Da, depending on tissue type and physiological conditions. HA production in vertebrates is strictly regulated by three hyaluronan synthases: HAS1, HAS2, and HAS3. Sequence analysis has shown that all HAS proteins are composed of multiple membrane-spanning regions and large cytoplasmic loops possessing catalytic motifs. Each HAS isozyme differs in such enzymatic properties as stability, substrate kinetics, and rate of sugar chain elongation and may thus synthesize distinct forms of HA (Itano et al. 1999).


Pulmonary Arterial Hypertension Idiopathic Pulmonary Arterial Hypertension Gastrula Stage Catalytic Motif Hyaluronan Synthases 
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Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.Department of Molecular Biosciences, Faculty of Life SciencesKyoto Sangyo UniversityKita-Ku, KyotoJapan
  2. 2.Advanced Medical Research CenterAichi Medical UniversityNagakuteJapan

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