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Core 1 β3Galactosyltransferase (C1GalT1, T-Synthase) and Its Specific Molecular Chaperone Cosmc (C1GalT1C1)

  • Tongzhong Ju
  • Richard D. Cummings
Reference work entry

Abstract

Core 1 UDP-Gal: N-acetylgalactosaminyl-α1-O-Ser/Thr β3galactosyltransferase (core 1 β3galactosyltransferase, core 1 β3GalT, C1GALT1, T-synthase, EC 2.4.1.122) transfers the Gal from UDP-Gal to N-acetylgalactosaminyl-α1-O-Ser/Thr (Tn antigen) in a protein to form Galβ1,3GalNAc-α-Ser/Thr, the core 1 structure also known as T antigen (Fig. 15.1) in the mucin-type O-glycosylation pathway. This core 1 structure is the most common precursor for a variety of complex structures of mucin-type O-glycans (O-glycans) usually found in many mucins, membrane glycoproteins, and secreted glycoproteins (Ju et al. 2011a). These O-glycans include mono- and di-sialyl core 1, sialyl Lewis x (SLeX) core 2 O-glycans with or without poly-N-acetyllactosamine structures, and extended core 1 O-glycans with sulfation such as sulfo-sialyl Lewis x (MECA79 epitope). The O-glycans on glycoproteins play important roles in immunity (Ellies et al. 1998; Homeister et al. 2001; Yeh et al. 2001), cell–cell interactions (selectins and their ligands) (Homeister et al. 2001; Leppanen et al. 1999; McEver et al. 1995; Wilkins et al. 1996; Yeh et al. 2001), vascular biology (Tenno et al. 2007), angiogenesis (Xia et al. 2004), lymphangiogenesis (Fu et al. 2008), and biogenesis and function of platelets (Wang et al. 2012). Biochemically and biologically, T-synthase is the key glycosyltransferase in the biosynthesis and biology of mucin-type O-glycan.

Keywords

Jurkat Cell Zebra Fish Baculovirus Expression System Single Exon Gene Bovine Submaxillary Mucin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.Department of BiochemistryEmory University School of MedicineAtlantaUSA

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