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Galactose-3-O-Sulfotransferase 1-4 (GAL3ST1-4)

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  • First Online:
Handbook of Glycosyltransferases and Related Genes

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Abstract

Galactose-3-O-sulfotranasferases (Gal3STs) are Golgi-membrane sulfotransferases catalyzing transfer of a sulfate group from the donor substrate, 3′-phosphoadenosine 5′-phosphosulfate (PAPS), to the C3 position of the nonreducing terminal β-Gal residue of carbohydrate chains. So far four Gal3STs have been identified, and their primary structures are found to be similar to each other (El-Fasakhany et al. 2001; Honke et al. 1997, 2001; Seko et al. 2001; Suzuki et al. 2001). The original Gal3ST gene was cloned as a gene that encodes galactosylceramide (GalCer) sulfotransferase (Honke et al. 1997) based on the amino acid sequence of the purified enzyme (Honke et al. 1996). The second through fourth Gal3ST genes were cloned by making use of homology to the GalCer sulfotransferase gene (El-Fasakhany et al. 2001; Honke et al. 2001; Seko et al. 2001; Suzuki et al. 2001). Although the characteristic and biological function of GalCer sulfotransferase (Gal3ST-1) have been extensively studied (Honke et al. 1997; Ishizuka 1997), reports on the other Gal3STs are limited. Therefore, this article mainly focuses on GalCer sulfotransferase (a.k.a. CST, Gal3ST-1).

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Authors and Affiliations

  1. Department of Biochemistry, Kochi University Medical School, Kohasu, Oko-cho, 783-8505, Nankoku, Kochi, Japan

    Prof. Koichi Honke

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  1. Prof. Koichi Honke
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Correspondence to Koichi Honke .

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Editors and Affiliations

  1. RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN, Wako, Saitama, Japan

    Naoyuki Taniguchi

  2. Department of Biochemistry, Kochi University, Medical School, Nankoku, Kochi, Japan

    Koichi Honke

  3. Sanford Burnham Medical Research Institute, La Jolla, California, USA

    Minoru Fukuda

  4. Research Center for Medical Glycoscience (RCMG), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan

    Hisashi Narimatsu

  5. RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN, Wako, Saitama, Japan

    Yoshiki Yamaguchi

  6. Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan

    Takashi Angata

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Honke, K. (2014). Galactose-3-O-Sulfotransferase 1-4 (GAL3ST1-4). In: Taniguchi, N., Honke, K., Fukuda, M., Narimatsu, H., Yamaguchi, Y., Angata, T. (eds) Handbook of Glycosyltransferases and Related Genes. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54240-7_56

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