Abstract
Fucose from extracellular sources or the degradation of glycoconjugates is converted after cellular uptake by a salvage pathway leading to the formation of GDP-fucose. The first step requires the synthesis of β-l-fucose-1-phosphate by an ATP-dependent kinase reaction, which is catalyzed by l-fucose kinase (fucokinase) (Fig. 143.1). GDP-fucose is then formed by action of GDP-fucose pyrophosphorylase. Depending on tissue and physiological state, the salvage pathway usually contributes about 10 % to the total GDP-fucose pool, which is mainly fed by de novo synthesis from GDP-mannose (Fig. 143.1). Afterwards GDP-fucose is transported to the Golgi apparatus, where the fucose moiety is transferred to growing glycoconjugates by specific fucosyltransferases.
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Hinderlich, S., Reinke, S. (2014). Fucokinase (FUK). In: Taniguchi, N., Honke, K., Fukuda, M., Narimatsu, H., Yamaguchi, Y., Angata, T. (eds) Handbook of Glycosyltransferases and Related Genes. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54240-7_52
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DOI: https://doi.org/10.1007/978-4-431-54240-7_52
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