Fucokinase (FUK)

  • Stephan Hinderlich
  • Stefan Reinke
Reference work entry


Fucose from extracellular sources or the degradation of glycoconjugates is converted after cellular uptake by a salvage pathway leading to the formation of GDP-fucose. The first step requires the synthesis of β-l-fucose-1-phosphate by an ATP-dependent kinase reaction, which is catalyzed by l-fucose kinase (fucokinase) (Fig. 143.1). GDP-fucose is then formed by action of GDP-fucose pyrophosphorylase. Depending on tissue and physiological state, the salvage pathway usually contributes about 10 % to the total GDP-fucose pool, which is mainly fed by de novo synthesis from GDP-mannose (Fig. 143.1). Afterwards GDP-fucose is transported to the Golgi apparatus, where the fucose moiety is transferred to growing glycoconjugates by specific fucosyltransferases.


Salvage Pathway Bifunctional Enzyme Radiometric Assay Porcine Thyroid Extracellular Source 
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Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.Department of Life Sciences and TechnologyBeuth Hochschule für Technik Berlin – University of Applied SciencesBerlinGermany

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