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Dolichyl-Phosphate Beta-Glucosyltransferase (ALG5)

  • Tetsuo Takahashi
Reference work entry

Abstract

Dolichyl-phosphate beta-glucosyltransferase (ALG5), which is localized on the rough endoplasmic reticulum (rER) membrane, catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to dolichyl-phosphate (Dol-P) to synthesize dolichol-phosphate glucose (Dol-P-Glc, DPG, Glc-P-Dol or GPD). Therefore, this enzyme is also called Dol-P-Glc synthase. Dol-P-Glc produced by this enzyme is utilized for glucosylation of intermediate dolichol-linked oligosaccharide (DLO), N-glycan precursor, by three glucosyltransferases (ALG6, ALG8, and ALG10 proteins) at final stages of its assembly pathway.

Keywords

Nonpermissive Temperature ALG5 Gene Alg5 Mutation Double Mutant Cell Yeast Microsome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.Department of Applied Biochemistry, School of EngineeringTokai UniversityHiratsukaJapan

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