Dolichyl-Phosphate Beta-Glucosyltransferase (ALG5)

  • Tetsuo Takahashi
Reference work entry


Dolichyl-phosphate beta-glucosyltransferase (ALG5), which is localized on the rough endoplasmic reticulum (rER) membrane, catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to dolichyl-phosphate (Dol-P) to synthesize dolichol-phosphate glucose (Dol-P-Glc, DPG, Glc-P-Dol or GPD). Therefore, this enzyme is also called Dol-P-Glc synthase. Dol-P-Glc produced by this enzyme is utilized for glucosylation of intermediate dolichol-linked oligosaccharide (DLO), N-glycan precursor, by three glucosyltransferases (ALG6, ALG8, and ALG10 proteins) at final stages of its assembly pathway.


Nonpermissive Temperature ALG5 Gene Alg5 Mutation Double Mutant Cell Yeast Microsome 
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Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.Department of Applied Biochemistry, School of EngineeringTokai UniversityHiratsukaJapan

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