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Cytidine Monophosphate N-Acetylneuraminic Acid Synthetase (CMAS)

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Book cover Handbook of Glycosyltransferases and Related Genes

Abstract

The cytidine monophosphate N-acetylneuraminic acid synthetase (CMAS) catalyzes the activation of the nine-carbon amino sugar N-acetylneuraminic acid (NeuAc) and other sialic acid (Sia) derivatives to the sugar nucleotide cytidine monophosphate N-acetylneuraminic acid (CMP-NeuAc or CMP-Sia) (Kean 1991) by the following reaction:

$$ \mathrm{CTP}+\mathrm{NeuAc}\to \mathrm{CMP}-\mathrm{NeuAc}+\mathrm{PPi} $$

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Authors and Affiliations

  1. Institute for Cellular Chemistry, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625, Hannover, Germany

    Dr. Birgit Weinhold, Dr. Rita Gerardy-Schahn & Dr. Anja Münster-Kühnel

Authors
  1. Dr. Birgit Weinhold
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  2. Dr. Rita Gerardy-Schahn
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  3. Dr. Anja Münster-Kühnel
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Corresponding author

Correspondence to Birgit Weinhold .

Editor information

Editors and Affiliations

  1. RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN, Wako, Saitama, Japan

    Naoyuki Taniguchi

  2. Department of Biochemistry, Kochi University, Medical School, Nankoku, Kochi, Japan

    Koichi Honke

  3. Sanford Burnham Medical Research Institute, La Jolla, California, USA

    Minoru Fukuda

  4. Research Center for Medical Glycoscience (RCMG), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan

    Hisashi Narimatsu

  5. RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN, Wako, Saitama, Japan

    Yoshiki Yamaguchi

  6. Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan

    Takashi Angata

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Weinhold, B., Gerardy-Schahn, R., Münster-Kühnel, A. (2014). Cytidine Monophosphate N-Acetylneuraminic Acid Synthetase (CMAS). In: Taniguchi, N., Honke, K., Fukuda, M., Narimatsu, H., Yamaguchi, Y., Angata, T. (eds) Handbook of Glycosyltransferases and Related Genes. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54240-7_39

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