ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 5,6 (ST6GALNAC5,6)
Generally, sialylation occurs in galactose residues at the nonreducing ends of carbohydrate chains with α,2,3- or α2,6-linkage. Sialyl polymer is synthesized by linking sialic acid and sialic acid by α2,8-linkage. In addition to these sialylation patterns, α2,6-linked sialic acids on GalNAc were found in O-glycans and gangliosides. ST6GalNAcI, II, III, and IV were isolated as α2,6-sialyltransferases mainly acting on GalNAc residues in O-glycans. In turn, α2,6-sialylated gangliosides were reported as minor gangliosides of alpha-series structures mainly in animal tissues (Hirabayashi et al. 1990). GD1alpha was also detected in Purkinje cells, disappearing in the mutant mice with Purkinje cell abnormality (Furuya et al. 1994), while the implication in the brain functions has not been investigated.
KeywordsSialic Acid Poly Glutamine Proximal Tubule Epithelial Cell GalNAc Residue cDNA Expression Vector
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