ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 5,6 (ST6GALNAC5,6)

  • Koichi Furukawa
  • Tetsuya Okajima
  • Akiko Tsuchida
  • Keiko Furukawa
Reference work entry


Generally, sialylation occurs in galactose residues at the nonreducing ends of carbohydrate chains with α,2,3- or α2,6-linkage. Sialyl polymer is synthesized by linking sialic acid and sialic acid by α2,8-linkage. In addition to these sialylation patterns, α2,6-linked sialic acids on GalNAc were found in O-glycans and gangliosides. ST6GalNAcI, II, III, and IV were isolated as α2,6-sialyltransferases mainly acting on GalNAc residues in O-glycans. In turn, α2,6-sialylated gangliosides were reported as minor gangliosides of alpha-series structures mainly in animal tissues (Hirabayashi et al. 1990). GD1alpha was also detected in Purkinje cells, disappearing in the mutant mice with Purkinje cell abnormality (Furuya et al. 1994), while the implication in the brain functions has not been investigated.


Sialic Acid Poly Glutamine Proximal Tubule Epithelial Cell GalNAc Residue cDNA Expression Vector 
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Copyright information

© Springer Japan 2014

Authors and Affiliations

  • Koichi Furukawa
    • 1
  • Tetsuya Okajima
    • 2
  • Akiko Tsuchida
    • 3
  • Keiko Furukawa
    • 4
  1. 1.Department of Biochemistry IINagoya University Graduate School of MedicineShowa-kuJapan
  2. 2.Department of Biochemistry IINagoya University Graduate School of MedicineShowa-kuJapan
  3. 3.Department of Biochemistry IINagoya University Graduate School of MedicineShowa-kuJapan
  4. 4.Department of Biomedical SciencesChubu University College of Life and Health SciencesKasugaiJapan

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