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ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 6 (ST3GAL6)

  • Tetsuya Okajima
  • Koichi Furukawa
Reference work entry

Abstract

ST3Gal6 (Uniprot ID: Q11203) is a member of the sialyltransferase family that transfers sialic acid from the activated cytidine 5′-monophospho-N-acetylneuraminic acid to terminal galactose on glycolipids (gangliosides) or the N- or O-linked sugar chains of glycoproteins in α2,3 linkage. ST3Gal6 has high specificity for neolactotetraosylceramide (paragloboside) and neolactohexaosylceramide as glycosphingolipid substrates and contributes to the formation of sialyl type II lactosamine and thereby Sialyl-Lewis X, a tetrasaccharide carbohydrate important for selectin-mediated cell adhesion and a blood group antigen.

Keywords

Blood Group Antigen Selectin Ligand Sialyltransferase Activity Prostate Adenocarcinoma Cell Line Bovine Submaxillary Gland 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

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Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.Department of Biochemistry IINagoya University Graduate School of MedicineShowa-kuJapan

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