UDP-Gal: Lactosylceramide Alpha 1,4-Galactosyltransferase (A4GALT)

  • Koichi Furukawa
  • Yuji Kondo
  • Keiko Furukawa
Reference work entry


UDP-Gal:lactosylceramide alpha 1,4-galactosyltransferase (A4GALT) catalyzes the transfer of galactose from UDP-galactose to lactosylceramide (Taga et al. 1995) as shown in Fig. 14.1. The product is called globotriaosylceramide (Gb3) or CD77. This structure is a molecule locating at the starting point for the synthesis of globo-series glycosphingolipids. Gb3 and more complex glycosphingolipids in this series are expressed in relatively restricted tissues and cells in our bodies, i.e., erythrocytes, kidney, endothelium, and some population of germinal center B lymphocytes (Klein et al. 1983). In human cancers, Burkitt’s lymphomas characteristically express Gb3 (Wiels et al. 1981).


Hemolytic Uremic Syndrome Endogenous Ligand Blood Group Antigen O157 Infection Complex Glycosphingolipids 
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Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.Department of Biochemistry IINagoya University Graduate School of MedicineShowa-kuJapan
  2. 2.Department of Biomedical SciencesChubu University College of Life and Health SciencesKasugaiJapan

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