N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl) 3,4 (NDST3,4)

  • Jun-ichi Aikawa
Reference work entry


Heparan sulfate (HS) and heparin are linear polysaccharides having glucosamine (GlcN)-uronic acid (UA) as a repeating unit (Esko and Lindahl 2001). UA moieties and sulfate groups in the polysaccharides give highly negative charges to heparan sulfate and heparin, which physiologically modulate local concentration and/or functional properties of heparin-binding proteins and, as a result, affect development and homeostasis and cause disease in living organisms (Esko and Selleck 2002; Bishop et al. 2007).


Catalytic Domain Heparan Sulfate Uronic Acid Acetic Anhydride Resistin Level 
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Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.Synthetic Cellular Chemistry Laboratory, RIKENSaitamaJapan

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