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N-Deacetylase/N-Sulfotransferase (Heparan Glucosaminyl) 3,4 (NDST3,4)

  • Jun-ichi Aikawa
Reference work entry

Abstract

Heparan sulfate (HS) and heparin are linear polysaccharides having glucosamine (GlcN)-uronic acid (UA) as a repeating unit (Esko and Lindahl 2001). UA moieties and sulfate groups in the polysaccharides give highly negative charges to heparan sulfate and heparin, which physiologically modulate local concentration and/or functional properties of heparin-binding proteins and, as a result, affect development and homeostasis and cause disease in living organisms (Esko and Selleck 2002; Bishop et al. 2007).

Keywords

Catalytic Domain Heparan Sulfate Uronic Acid Acetic Anhydride Resistin Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.Synthetic Cellular Chemistry Laboratory, RIKENSaitamaJapan

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