Protein O-Mannosyl-transferase 1,2 (POMT1,2)

  • Hiroshi Manya
  • Tamao Endo
Reference work entry


Protein O-mannosyltransferase 1 (POMT1) and POMT2 catalyze the initial step of the biosynthesis of O-mannosyl glycans, in which a mannosyl residue is transferred from dolichyl-phosphate mannose (Dol-P-Man) to Ser/Thr residues of certain proteins as shown in Fig. 16.1. POMT1 and POMT2 localize in the endoplasmic reticulum (ER) and have seven- and nine-transmembrane helices, respectively, in which the C-termini and loops 1, 3, and 5 are located in the ER lumen. Complex formation of POMT1 and POMT2 is indispensable for POMT activity (Akasaka-Manya et al. 2006; Manya et al. 2004). Respective roles of POMT1 and POMT2 on POMT activity have not been elucidated so far.


Microsomal Membrane Endoplasmic Reticulum Lumen Ocular Abnormality Congenital Muscular Dystrophy Mannosyl Residue 
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Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.Molecular GlycobiologyTokyo Metropolitan Geriatric Hospital and Institute of GerontologyItabashi-kuJapan

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