Map 2: Biosynthetic Pathways of O-Glycans

  • Hiroshi Nakada
Reference work entry


O-Glycosylation is a common covalent modification of Ser and Thr residues of mammalian glycoproteins. In addition to mucin-type O-glycans, there are several types of non-mucin-type O-glycans, including α-linked O-Fuc, β-linked O-Xyl, α-linked O-Man, β-linked O-GlcNAc, and so on. In this section, however, the term O-glycan refers to mucin-type O-glycans. O-Linked mucin-type oligosaccharides are not preassembled on a dolichol derivative, but every sugar is transferred individually from a specific nucleotide sugar. O-Glycosylation is initiated by the transfer of GalNAc to Thr or Ser of the polypeptide. Eight O-glycan core structures can be biosynthesized, followed by elongation and terminal glycosylation as shown in Fig. 148.1.


Backbone Structure Human Ovarian Tissue Lewis Blood Group Bovine Submaxillary Mucin Common Core Structure 
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Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.Department of Molecular SciencesFaculty of Life Sciences, Kyoto Sangyo UniversityKamigamo-Motoyama, Kita-kuJapan

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