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Glutamine–Fructose-6-Phosphate Transaminase 1,2 (GFPT1,2)

  • Kazuto Yamazaki
Reference work entry

Abstract

l-Glutamine–d-fructose-6-phosphate transaminase (GFPT) is the first and rate-limiting enzyme of the hexosamine biosynthesis pathway (HBP). GFPT converts d-fructose-6-phosphate (Fru-6-P) and l-glutamine to d-glucosamine-6-phosphate (GlcN-6-P) and l-glutamate. GlcN-6-P is an essential precursor of hexosamines, such as uridine 5′-diphosphate-N-acetyl-d-glucosamine (UDP-GlcNAc). UDP-GlcNAc is a substrate for synthesis of glycoproteins, proteoglycans, and glycolipids and moreover for the posttranslational modification of proteins with O-linked β-N-acetylglucosamine (O-GlcNAc) on serine and threonine residues, which is an important step for the regulation of intracellular signaling. Figure 129.1 is a schematic representation of the HBP, which includes the synthesis of GlcNAcylated proteins.

Keywords

Diabetic Nephropathy Endoplasmic Reticulum Stress High Glucose Level Blastocyst Formation Congenital Myasthenic Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.Tsukuba Research LaboratoriesEisai Co., LtdTsukubaJapan

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