UDP-N-Acetylglucosamine Pyrophosphorylase 1 (UAP1)

  • Hisafumi Okabe
  • Toshiyuki Mio
Reference work entry


Uridine-diphospho-N-acetylglucosamine (UDP-GlcNAc) is an essential precursor of N- or O-linked glycosylation in important metabolic processes (Hart et al. 1989; Herscovics and Orlean 1993). It is known as a substrate of chitin synthase, the product of which is essential for fungal cell wall (Cabib et al. 1982; Milewski et al. 2006), and it also plays important roles in cell wall peptidoglycan synthesis and the disaccharide moiety of lipid A in bacteria (Raetz 1996).


Malachite Green Neurospora Crassa Fungal Cell Wall cDNA Expression Library Antisperm Antibody 
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Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.Chugai Pharmaceutical Co. LTDKamakura, KanagawaJapan
  2. 2.Research DivisionChugai Pharmaceutical Co. LTDKamakura, KanagawaJapan

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