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UDP-N-Acetylglucosamine Pyrophosphorylase 1 (UAP1)

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Handbook of Glycosyltransferases and Related Genes

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Abstract

Uridine-diphospho-N-acetylglucosamine (UDP-GlcNAc) is an essential precursor of N- or O-linked glycosylation in important metabolic processes (Hart et al. 1989; Herscovics and Orlean 1993). It is known as a substrate of chitin synthase, the product of which is essential for fungal cell wall (Cabib et al. 1982; Milewski et al. 2006), and it also plays important roles in cell wall peptidoglycan synthesis and the disaccharide moiety of lipid A in bacteria (Raetz 1996).

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Author information

Authors and Affiliations

  1. Chugai Pharmaceutical Co. LTD, Kamakura, Kanagawa, Japan

    Dr. Hisafumi Okabe

  2. Research Division, Chugai Pharmaceutical Co. LTD, 200 Kajiwara, 247-8530, Kamakura, Kanagawa, Japan

    Dr. Toshiyuki Mio

Authors
  1. Dr. Hisafumi Okabe
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  2. Dr. Toshiyuki Mio
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Corresponding author

Correspondence to Hisafumi Okabe .

Editor information

Editors and Affiliations

  1. RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN, Wako, Saitama, Japan

    Naoyuki Taniguchi

  2. Department of Biochemistry, Kochi University, Medical School, Nankoku, Kochi, Japan

    Koichi Honke

  3. Sanford Burnham Medical Research Institute, La Jolla, California, USA

    Minoru Fukuda

  4. Research Center for Medical Glycoscience (RCMG), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan

    Hisashi Narimatsu

  5. RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN, Wako, Saitama, Japan

    Yoshiki Yamaguchi

  6. Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan

    Takashi Angata

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© 2014 Springer Japan

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Okabe, H., Mio, T. (2014). UDP-N-Acetylglucosamine Pyrophosphorylase 1 (UAP1). In: Taniguchi, N., Honke, K., Fukuda, M., Narimatsu, H., Yamaguchi, Y., Angata, T. (eds) Handbook of Glycosyltransferases and Related Genes. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54240-7_153

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