Handbook of Glycosyltransferases and Related Genes pp 1425-1437 | Cite as
UDP-Glucose 6-Dehydrogenase (UGDH)
Uridine diphosphate-α-d-glucose 6-dehydrogenase (UGDH, EC 188.8.131.52) is the four-electron transfer enzyme responsible for the oxidation of 6-hydroxyl group of UDP-α-d-glucose (UDP-Glc) to produce UDP-α-d-glucuronic acid (UDP-GlcA). The latter is the substrate for numerous transferases (described elsewhere in this book) which are engaged in the synthesis of hyaluronan (HA), heparin/heparan sulfate, and chondroitin/dermatan sulfate and numerous glucuronides essential in the detoxification of xenobiotics and toxic or insoluble products of metabolism. UDP-GlcA can also be enzymatically decarboxylated to form UDP-xylose, the priming sugar in the synthesis of sulfated glycosaminoglycans (GAGs). UDP-xylose is also an endogenous negative feedback inhibitor of UGDH activity.
KeywordsSulfated Glycosaminoglycan Cysteine Thiol Hyaluronan Synthesis Bovine Enzyme Crude Tissue Extract
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