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UDP-Glucose 6-Dehydrogenase (UGDH)

  • Yanusz Wegrowski
  • Andrew A. Pitsillides
Reference work entry

Abstract

Uridine diphosphate-α-d-glucose 6-dehydrogenase (UGDH, EC 1.1.1.22) is the four-electron transfer enzyme responsible for the oxidation of 6-hydroxyl group of UDP-α-d-glucose (UDP-Glc) to produce UDP-α-d-glucuronic acid (UDP-GlcA). The latter is the substrate for numerous transferases (described elsewhere in this book) which are engaged in the synthesis of hyaluronan (HA), heparin/heparan sulfate, and chondroitin/dermatan sulfate and numerous glucuronides essential in the detoxification of xenobiotics and toxic or insoluble products of metabolism. UDP-GlcA can also be enzymatically decarboxylated to form UDP-xylose, the priming sugar in the synthesis of sulfated glycosaminoglycans (GAGs). UDP-xylose is also an endogenous negative feedback inhibitor of UGDH activity.

Keywords

Sulfated Glycosaminoglycan Cysteine Thiol Hyaluronan Synthesis Bovine Enzyme Crude Tissue Extract 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.Laboratoire de Biochimie Médicale et Biologie MoléculaireUniversité; de ReimsReimsFrance
  2. 2.Department of Veterinary Basic SciencesRoyal Veterinary CollegeLondonUK

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