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UDP-N-Acetyl-Alpha-D-Galactosamine: Polypeptide N-Acetylgalactosaminyltransferases (ppGalNAc-Ts)

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Handbook of Glycosyltransferases and Related Genes

Abstract

Mucin-type O-linked glycosylation is initiated by the UDP-N-acetyl-α-d-galactosamine:polypeptide N-acetylgalactosaminyltransferases (ppGalNAc-Ts), which catalyze the addition of N-acetylgalactosamine (GalNAc) in an alpha-anomeric linkage to the hydroxyl groups of serines or threonines (Fig. 46.1). The ppGalNAc-Ts belong to family 27 of the retaining nucleotide-diphospho-sugar transferases, based on amino acid sequence similarities. The initial transfer of GalNAc from the nucleotide sugar UDP-GalNAc onto protein substrates occurs in the Golgi apparatus and can then be followed by the subsequent addition of other saccharides to form extended and branched mucin-type O-glycans.

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Authors and Affiliations

  1. NIDCR/National Institutes of Health, 30 Convent Drive, MSC 4370, Bld. 30/Rm 426, Bethesda, MD, 20892-4370, USA

    Dr. Liping Zhang, Dr. E. Tian & Dr. Kelly G. Ten Hagen

Authors
  1. Dr. Liping Zhang
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  2. Dr. E. Tian
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  3. Dr. Kelly G. Ten Hagen
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Editor information

Editors and Affiliations

  1. RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN, Wako, Saitama, Japan

    Naoyuki Taniguchi

  2. Department of Biochemistry, Kochi University, Medical School, Nankoku, Kochi, Japan

    Koichi Honke

  3. Sanford Burnham Medical Research Institute, La Jolla, California, USA

    Minoru Fukuda

  4. Research Center for Medical Glycoscience (RCMG), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan

    Hisashi Narimatsu

  5. RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN, Wako, Saitama, Japan

    Yoshiki Yamaguchi

  6. Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan

    Takashi Angata

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© 2014 Springer Japan

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Zhang, L., Tian, E., Ten Hagen , K.G. (2014). UDP-N-Acetyl-Alpha-D-Galactosamine: Polypeptide N-Acetylgalactosaminyltransferases (ppGalNAc-Ts). In: Taniguchi, N., Honke, K., Fukuda, M., Narimatsu, H., Yamaguchi, Y., Angata, T. (eds) Handbook of Glycosyltransferases and Related Genes. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54240-7_139

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