ST6 N-Acetylgalactosaminide Alpha-2,6-Sialyltransferase 4 (ST6GALNAC4)

  • Shou Takashima
  • Shuichi Tsuji
Reference work entry


ST6GalNAc-III, ST6GalNAc-IV, ST6GalNAc-V, and ST6GalNAc-VI are members of NeuAcα2-3Galβ1-3GalNAc α2,6-sialyltransferases. These members except ST6GalNAc-IV can efficiently synthesize the ganglioside GD1α from GM1b (Sjoberg et al. 1996; Lee et al. 1999; Okajima et al. 1999, 2000; Ikehara et al. 1999; Harduin-Lepers et al. 2000; Tsuchida et al. 2005; Ko et al. 2010). Compared with other members, ST6GalNAc-IV prefers O-linked glycans of glycoproteins to glycolipids as substrates. Therefore, ST6GalNAc-IV may be the main candidate for synthesizing the NeuAcα2-3Galβ1-3(NeuAcα2-6)GalNAc residue, which is usually found in the O-glycans. ST6GalNAc-IV is also considered to be involved in the early alteration of the sialylation pattern of cell surface molecules in activated lymphocytes (Kaufmann et al. 1999). Like ST6GalNAc-III, ST6GalNAc-IV is a relatively small sialyltransferase (302 amino acids in length for human, mouse, and pig enzymes) compared with other animal sialyltransferases because of the short stem region. However, isoforms of ST6GalNAc-IV with different amino acid length are also reported (350 and 360 amino acids in length for mouse isoforms). The overall amino acid sequence identity of mouse ST6GalNAc-IV is 88.4 % to human ST6GalNAc-IV, 86.1 % to pig ST6GalNAc-IV, 43.0 % to mouse ST6GalNAc-III, 44.8 % to mouse ST6GalNAc-V, and 41.2 % to mouse ST6GalNAc-VI, respectively, but ST6GalNAc-IV shows no significant similarity to other sialyltransferases except in sialylmotifs.


Acceptor Substrate mRNA Differential Display Amino Acid Length GalNAc Residue Differential Display Polymerase Chain Reaction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.Laboratory of GlycobiologyThe Noguchi InstituteItabashiJapan
  2. 2.Institute of GlycoscienceTokai UniversityHiratsukaJapan

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