Dolichyl-Phosphate Mannosyltransferase Polypeptide (DPM1-3)

  • Tetsuo Takahashi
Reference work entry


Dolichyl-phosphate mannosyltransferase polypeptide catalyzes the transfer of mannose from GDP-mannose (GDP-Man) to dolichyl-phosphate (Dol-P) to produce dolichol-phosphate mannose (Dol-P-Man or DPM). Hence, it is also called DPM synthase. Although this enzyme is widely conserved among eukaryotes, its existing form is mainly divided into two classes; in budding yeast, fungi, and protozoa, dolichyl-phosphate mannosyltransferase exists as one polypeptide (Dpm1p), whereas it consists of three polypeptides (DPM1-3) in fission yeast, worm, and vertebrate (Colussi et al. 1997; Maeda et al. 2000). DPM yielded by this enzyme is utilized as a mannosyl donor for biosynthetic pathways of dolichol-linked oligosaccharide (DLO; N-glycan precursor), glycosylphosphatidylinositol (GPI) anchor, protein O-mannosylation, and protein C-mannosylation on the rough endoplasmic reticulum (rER) membrane. Thus, biosynthesis of these types of glycans might be all affected by any deficiency of the enzyme.


Parotid Acinar Cell Guanosine Diphosphate Chinese Hamster Ovary Cell Mutant Hamster Ovary Cell Mutant Aberrant Cell Wall 
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Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.Department of Applied Biochemistry, School of EngineeringTokai UniversityHiratsukaJapan

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