N-Acetylneuraminic Acid Synthase (NANS)

  • Michael J. Betenbaugh
  • Bojiao Yin
  • Emily Blake
  • Linda Kristoffersen
  • Someet Narang
  • Karthik Viswanathan
Reference work entry


The human gene NANS, also known as sialic acid (phosphate) synthase (SAS), encodes N-acetylneuraminic acid 9-phosphate synthase (Neu5Ac-9-P synthase), a cytosolic protein approximately 40 kDa in size and comprising 359 amino acids (Lawrence et al. 2000). Neu5Ac-9-P synthase plays a pivotal role in the primary synthesis of the most common sialic acid, N-acetylneuraminic acid (Neu5Ac, NeuNAc, or NeuAc). However, studies have shown that NANS can also contribute in humans to the enzymatic synthesis of other sialic acids including 2-keto-3-deoxy-d-glycero-d-galacto-nononic acid (KDN). Furthermore, as a critical step along the pathway towards the production of the principal sialylation substrates, CMP-Neu5Ac and CMP-Neu5Gc, NANS can also influence the sialylation of glycans in important ways.


Sialic Acid Down Syndrome Neural Cell Adhesion Molecule Neisseria Meningitidis Antifreeze Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Japan 2014

Authors and Affiliations

  • Michael J. Betenbaugh
    • 1
  • Bojiao Yin
    • 1
  • Emily Blake
    • 1
  • Linda Kristoffersen
    • 1
  • Someet Narang
    • 2
  • Karthik Viswanathan
    • 3
  1. 1.Department of Chemical and Biomolecular EngineeringJohns Hopkins UniversityBaltimoreUSA
  2. 2.MedImmuneGaithersburgUSA
  3. 3.Department of Biological EngineeringMassachusetts Institute of TechnologyCambridgeUSA

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