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Handbook of Glycosyltransferases and Related Genes pp 515–530Cite as

Fucosyltransferases 1, 2. GDP-Fucose Galactoside α2-Fucosyltransferases. FUT1 or H Blood Group, FUT2 or ABH Secretor Status and Sec1 (FUT1, FUT2, Sec1)

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Abstract

Two groups of fucosyltransferases have been found based on the presence of highly conserved peptide motifs. The first group is constituted by three families of enzymes, namely, the α2-fucosyltransferases (FUT1, FUT2, and Sec1), the α6-fucosyltransferase (FUT8), and the protein-O-fucosyltransferases (POFUT1 and POFUT2), and is defined by the presence of three conserved peptide motifs that constitute a signature for this first group (Martinez-Duncker et al. 2003). The second group comprises the α3-fucosyltransferases (FUT4, FUT5, FUT6, FUT7, FUT9, FUT10, and FUT11) and the α4-fucosyltransferases (FUT3 and FUT5). They are defined by the presence of five conserved peptide motifs, which constitute also a signature for this group of enzymes (Mollicone et al. 2009).

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Authors and Affiliations

  1. Inserm U1004 Reponses cellulaires au microenvironement et cancer, CNRS et L’Université de Paris Sud XI, 16, avenue Paul-Vaillant-Couturier, 94807, Villejuif, France

    Dr. Rafael Oriol

  2. Reponses cellulaires au microenvironement et cancer, CNRS and INSERM U1004, 16 Av Paul Vaillant-Couturier, 94807, Villejuif, France

    Dr. Rosella Mollicone

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  1. Dr. Rafael Oriol
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  2. Dr. Rosella Mollicone
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Correspondence to Rafael Oriol .

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Editors and Affiliations

  1. RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN, Wako, Saitama, Japan

    Naoyuki Taniguchi

  2. Department of Biochemistry, Kochi University, Medical School, Nankoku, Kochi, Japan

    Koichi Honke

  3. Sanford Burnham Medical Research Institute, La Jolla, California, USA

    Minoru Fukuda

  4. Research Center for Medical Glycoscience (RCMG), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan

    Hisashi Narimatsu

  5. RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN, Wako, Saitama, Japan

    Yoshiki Yamaguchi

  6. Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan

    Takashi Angata

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Oriol, R., Mollicone, R. (2014). Fucosyltransferases 1, 2. GDP-Fucose Galactoside α2-Fucosyltransferases. FUT1 or H Blood Group, FUT2 or ABH Secretor Status and Sec1 (FUT1, FUT2, Sec1). In: Taniguchi, N., Honke, K., Fukuda, M., Narimatsu, H., Yamaguchi, Y., Angata, T. (eds) Handbook of Glycosyltransferases and Related Genes. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54240-7_105

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