Fucosyltransferases 1, 2. GDP-Fucose Galactoside α2-Fucosyltransferases. FUT1 or H Blood Group, FUT2 or ABH Secretor Status and Sec1 (FUT1, FUT2, Sec1)

  • Rafael Oriol
  • Rosella Mollicone
Reference work entry


Two groups of fucosyltransferases have been found based on the presence of highly conserved peptide motifs. The first group is constituted by three families of enzymes, namely, the α2-fucosyltransferases (FUT1, FUT2, and Sec1), the α6-fucosyltransferase (FUT8), and the protein-O-fucosyltransferases (POFUT1 and POFUT2), and is defined by the presence of three conserved peptide motifs that constitute a signature for this first group (Martinez-Duncker et al. 2003). The second group comprises the α3-fucosyltransferases (FUT4, FUT5, FUT6, FUT7, FUT9, FUT10, and FUT11) and the α4-fucosyltransferases (FUT3 and FUT5). They are defined by the presence of five conserved peptide motifs, which constitute also a signature for this group of enzymes (Mollicone et al. 2009).


Exocrine Secretion Acceptor Substrate Leukocyte Adhesion Deficiency Human FUT1 Single Common Ancestor 
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© Springer Japan 2014

Authors and Affiliations

  1. 1.Inserm U1004 Reponses cellulaires au microenvironement et cancerCNRS et L’Université de Paris Sud XIVillejuifFrance
  2. 2.Reponses cellulaires au microenvironement et cancerCNRS and INSERM U1004VillejuifFrance

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