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Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase, Isozyme A,B (MGAT4A,B)

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Handbook of Glycosyltransferases and Related Genes

Abstract

Branches of complex-type multi-antennary N-glycan possess various carbohydrate moieties to interact with other molecules and exert micromolecular influences to their carrier proteins and counterpart molecules. Thereby, regulation of the branch formation on N-glycans is important for the maintenance of cellular homeostasis in whole body (Ohtsubo and Marth 2006). Indeed, amount of the fractions of multi-antennary N-glycans of bioactive glycoproteins is altered in response to physiological conditions that modulate their biological activities. The number and complexity of antennae primarily reflect the portfolio of expressed N-acetylglucosaminyltransferases (GnTs) and processing enzymes (Schachter 1991). GnT-IV is an indispensable enzyme producing multi-antennary N-glycans cooperatively with GnT-V. GnT-IV gene family consists of three genes named GnT-IVa, GnT-IVb, and GnT-IV-H, respectively (Minowa et al. 1998; Yoshida et al. 1998; Sakamoto et al. 2000). GnT-IVa and GnT-IVb isoenzymes have GnT-IV enzymatic activity and share substrate specificity with different tissue distribution profiles. In the past decades, the pathophysiological significance of the GnT-IV-dependent production of complex-type multi-antennary N-glycans has been gradually revealed. Attenuation and aberrant induction of GnT-IV enzymatic activity are associated with pathogenesis of grievous diseases.

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Author information

Authors and Affiliations

  1. Department of Analytical Biochemistry, School of Health Sciences, Kumamoto University, 4-24-1 Kuhonji, Chuo-ku, 862-0976, Kumamoto, Japan

    Dr. Kazuaki Ohtsubo

  2. Disease Glycomics Team, Systems Glycobiology Research Group, RIKEN-Max Planck Joint Research Center for Systems Chemical Biology, Global Research Cluster, RIKEN, 2-1 Hirosawa, 351-0198, Wako, Saitama, Japan

    Prof. Naoyuki Taniguchi

Authors
  1. Dr. Kazuaki Ohtsubo
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  2. Prof. Naoyuki Taniguchi
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Corresponding authors

Correspondence to Kazuaki Ohtsubo or Naoyuki Taniguchi .

Editor information

Editors and Affiliations

  1. RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN, Wako, Saitama, Japan

    Naoyuki Taniguchi

  2. Department of Biochemistry, Kochi University, Medical School, Nankoku, Kochi, Japan

    Koichi Honke

  3. Sanford Burnham Medical Research Institute, La Jolla, California, USA

    Minoru Fukuda

  4. Research Center for Medical Glycoscience (RCMG), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki, Japan

    Hisashi Narimatsu

  5. RIKEN-Max-Planck Joint Research Center for Systems Chemical Biology, RIKEN, Wako, Saitama, Japan

    Yoshiki Yamaguchi

  6. Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan

    Takashi Angata

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Ohtsubo, K., Taniguchi, N. (2014). Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase, Isozyme A,B (MGAT4A,B). In: Taniguchi, N., Honke, K., Fukuda, M., Narimatsu, H., Yamaguchi, Y., Angata, T. (eds) Handbook of Glycosyltransferases and Related Genes. Springer, Tokyo. https://doi.org/10.1007/978-4-431-54240-7_102

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