Advertisement

ALG Mannosyltransferases, ER Lumen = Alpha Linkage (ALG3,9,12)

  • Markus Aebi
Reference work entry

Abstract

N-linked protein glycosylation initiates in the endoplasmic reticulum by the assembly of the Glc3Man9GlcNAc2 oligosaccharide on the lipid carrier dolichylpyrophosphate. This oligosaccharide is transferred by oligosaccharyltransferase to selected asparagine residues of different polypeptide chains translocated into the lumen of the ER.

Keywords

ALG3 Protein ALG3 Activity Mannosyl Residue Mutate Yeast Cell Multiple Transmembrane Domain 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Aebi M, Gassenhuber J, Domdey H, Heesen ST (1996) Cloning and characterization of the ALG3 gene of Saccharomyces cerevisiae. Glycobiology 6:439–444PubMedCrossRefGoogle Scholar
  2. Burda P, Aebi M (1999) The dolichol pathway of N-linked glycosylation. Biochim Biophys Acta 1426:239–257PubMedCrossRefGoogle Scholar
  3. Haeuptle MA, Hennet T (2009) Congenital disorders of Glycosylation: an update on defects affecting the biosynthesis of dolichol-linked oligosaccharides. Hum Mutat 30:1628–1641PubMedCrossRefGoogle Scholar
  4. Huffaker TC, Robbins PW (1982) Temperature-sensitive yeast mutants deficient in asparagine-linked glycosylation. J Biol Chem 257:3203–3210PubMedGoogle Scholar
  5. Huffaker TC, Robbins PW (1983) Yeast mutants deficient in protein glycosylation. Proc Natl Acad Sci USA 80:7466–7470PubMedCrossRefGoogle Scholar
  6. Knauer R, Lehle L (1999) The N-oligosaccharyltransferase complex from yeast. FEBS Lett 311:83–86Google Scholar
  7. Knauer R, Lehle L, Hanefeld F, von Figura K (1994) Normal N-oligosaccharyltransferase activity in fibroblasts from patients with carbohydrate deficient glycoprotein syndrome. J Inherit Metab Dis 17:541–544PubMedCrossRefGoogle Scholar
  8. Korner C, Knauer R, Stephani U, Marquardt T, Lehle L, von Figura K (1999) Carbohydrate deficient glycoprotein syndrome type IV: deficiency of dolichyl-P-Man: Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase. EMBO J 18:6816–6822PubMedCrossRefGoogle Scholar
  9. Kurzik-Dumke U, Kaymer M, Gundacker D, Debes A, Labitzke K (1997) Gene within gene configuration and expression of the Drosophila melanogaster genes lethal(2) neighbour of tid [l(2)not] and lethal(2) relative of tid[l(2)rot]. Gene 200:45–58PubMedCrossRefGoogle Scholar
  10. Lairson LL, Henrissat B, Davies GJ, Withers SG (2008) Glycosyltransferases: structures, functions, and mechanisms. Annu Rev Biochem 77:521–555PubMedCrossRefGoogle Scholar
  11. Lizak C, Gerber S, Numao S, Aebi M, Locher KP (2011) X-ray structure of a bacterial oligosaccharyltransferase. Nature 474:350–355PubMedCrossRefGoogle Scholar
  12. Sharma CB, Knauer R, Lehle L (2001) Biosynthesis of lipid-linked oligosaccharides in yeast: the ALG3 gene encodes the Dol-P-Man: Man5GlcNAc2-PP-Dol mannosyltransferase. Biol Chem 382:321–328PubMedCrossRefGoogle Scholar

Copyright information

© Springer Japan 2014

Authors and Affiliations

  1. 1.Institut f. MikrobiologieETH ZürichZürichSwitzerland

Personalised recommendations