Introduction
Constant exposure to ionizing radiation is a “fact of life” for all life forms on Earth – for example, 90% of the annual radiation dose for a person living in the US comes from natural sources such as cosmic radiation and radioactive rocks (Early and Sodee 1995). However, fungi seem to interact with the ionizing radiation in a manner that may differ from other life forms. Large quantities of highly melanized fungal spores have been found in early Cretaceous period deposits when many species of animals and plants died out. This time period coincides with Earth’s crossing the “magnetic zero” resulting in the loss of its “shield” against cosmic radiation (Hulot and Gallet 2003). When exposed to high doses of ionizing radiation under experimental conditions, fungi in general, and especially melanized ones, are highly radioresistant (Saleh et al. 1988; Dembitzer et al. 1972; Dadachova et al. 2004; Mirchink et al. 1972). As ionizing radiation is perceived to be harmful to life,...
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Alekhova TA, Aleksandrova AA, Novozhilova TIu, Lysak LV, Zagustina NA, Bezborodov AM (2005) Monitoring of microbial degraders in manned space stations. Prikl Biokhim Mikrobiol 41:435–443
Baranov VM, Polikarpov NA, Novikova ND, Deshevaia EA, Poddubko SV, Svistunova IuV, Tsetlin VV (2006) Main results of the Biorisk experiment on the International Space Station. Aviakosm Ekolog Med 40:3–9
Bomford CK, Kunkler IH (2002) Walter and Miller’s textbook of radiotherapy: radiation physics, therapy, and oncology. Churchill Livingstone, London
Dadachova E, Howell RW, Bryan RA, Frenkel A, Nosanchuk JD, Casadevall A (2004) Susceptibility of the human pathogenic fungi Cryptococcus neoformans and Histoplasma capsulatum to gamma-radiation versus radioimmunotherapy with alpha- and beta-emitting radioisotopes. J Nucl Med 45:313–320
Dadachova E, Bryan RA, Huang X, Moadel T, Schweitzer AD, Aisen P, Nosanchuk JD, Casadevall A (2007) Ionizing radiation changes the electronic properties of melanin and enhances the growth of melanized fungi. PLoS One 5:e457
Dadachova E, Bryan RA, Howell RC, Schweitzer AD, Aisen P, Nosanchuk JD, Casadevall A (2008) Radioprotective properties of melanin are a function of its chemical composition, free stable radical presence and spatial arrangement. Pigment Cell Melanoma Res 21:192–199
Dembitzer HM, Buza I, Reiss F (1972) Biological and electron microscopic changes in gamma radiated Cryptococcus neoformans. Mycopathol Mycol Appl 47:307–315
Dighton J, Tugay T, Zhdanova N (2008) Fungi and ionizing radiation from radionuclides. FEMS Microbiol Lett 281:109–120
Early PJ, Sodee DB (1995) Principles and practice of nuclear medicine, 2nd edn. C.V. Mosby, St Louis
Eisenman HC, Nosanchuk JD, Webber JB, Emerson RJ, Camesano TA, Casadevall A (2005) Microstructure of cell wall-associated melanin in the human pathogenic fungus Cryptococcus neoformans. Biochemistry 44:3683–3693
Hall EJ (2000) Radiobiology for the radiologist. Lippincott Williams & Willkins, Philadelphia
Hulot G, Gallet Y (2003) Do superchrons occur without any palaeomagnetic warning? Earth Planet Sci Lett 210:191–201
Imshenetsky AA, Lysenko SV, Kazakov GA (1978) Upper boundary of the biosphere. Appl Environ Microbiol 35:1–5
Ito S, Fujita K (1985) Microanalysis of eumelanin and pheomelanin in hair and melanomas by chemical degradation and liquid chromatography. Anal Biochem 144:527–536
Karpenko YV, Redchitz TI, Zheltonozhsky VA, Dighton J, Zhdanova NN (2006) Comparative responses of microscopic fungi to ionizing radiation and light. Folia Microbiol (Praha) 51:45–49
Mal'tsev VN, Saadavi A, Aĭiad A, El'gaui O, Shlip M (1996) Microecology of nuclear reactor pool water. Radiats Biol Radioecol 36:52–57
Meredith P, Sarna T (2006) The physical and chemical properties of eumelanin. Pigment Cell Melanoma Res 19:572–594
Mirchink TG, Kashkina GB, Abaturov ID (1972) Resistance of fungi with different pigments to radiation. Mikrobiologiia 41:83–86
Mironenko NV, Alekhina IA, Zhdanova NN, Bulat SA (2000) Intraspecific variation in gamma-radiation resistance and genomic structure in the filamentous fungus Alternaria alternata: a case study of strains inhabiting Chernobyl reactor no. 4. Ecotoxicol Environ Saf 45:177–187
Mosse I, Kostrova L, Subbot S, Maksimenya I, Molophei V (2000) Melanin decreases clastogenic effects of ionizing radiation in human and mouse somatic cells and modifies the radioadaptive response. Radiat Environ Biophys 39:47–52
Nicolaus RA (1968) Melanins. Hermann, Paris
Novikova N, De Boever P, Poddubko S, Deshevaya E, Polikarpov N, Rakova N, Coninx I, Mergeay M (2006) Survey of environmental biocontamination on board the International Space Station. Res Microbiol 157:5–12
Novikova ND, Polikarpov NA, Deshevaia EA, Svistunova IuV, Grigor'ev AI (2007) Results of the experiment with extended exposure of microorganisms in open space. Aviakosm Ekolog Med 41:14–20
Robinson CH (2001) Cold adaptation in Arctic and Antarctic fungi. New Phytol 151:341–353
Saleh YG, Mayo MS, Ahearn DG (1988) Resistance of some common fungi to gamma irradiation. Appl Environ Microbiol 54:2134–2135
Schweitzer A, Howell RC, Jiang Z, Bryan RA, Gerfen G, Chen C-C, Mah D, Cahill S, Casadevall A, Dadachova E (2009) Physico-chemical evaluation of rationally designed melanins as novel nature-inspired radioprotectors. PLoS One 4:e7229
Sghaier H, Ghedira K, Benkahla A, Barkallah I (2008) Basal DNA repair machinery is subject to positive selection in ionizing-radiation-resistant bacteria. BMC Genom 9:297–304
Tugay T, Zhdanova NN, Zheltonozhsky V, Sadovnikov L, Dighton J (2006) The influence of ionizing radiation on spore germination and emergent hyphal growth response reactions of microfungi. Mycologia 98:521–527
Tugay TI, Zhdanova NN, Zheltonozhskiy VA, Sadovnikov LV (2007) Development of radioadaptive properties for microscopic fungi, long time located on terrains with a heightened background radiation after emergency on Chernobyl NPP. Radiats Biol Radioecol 47:543–549
Wakamatsu K, Ito S (2002) Advanced chemical methods in melanin determination. Pigment Cell Res 15:174–183
Wang Y, Aisen P, Casadevall A (1996) Melanin, melanin “ghosts,” and melanin composition in Cryptococcus neoformans. Infect Immun 64:2420–2424
Zhdanova NN, Lashko TN, Vasiliveskaya AI, Bosisyuk LG, Sinyavskaya OI, Gavrilyuk VI, Muzalev PN (1991) Interaction of soil micromycetes with ‘hot’ particles in the model system. Microbiol Zhurnal 53:9–17
Zhdanova NN, Redchitz TI, Krendyasova VG, Lashko TN, Gavrilyuk VI, Muzalev PI, Shcherbachenko AM (1994) Tropism of soil micromycetes under the influence of ionizing radiation. Mycol Fitopatol 28:8–13
Zhdanova NN, Tugay T, Dighton J, Zheltonozhsky V, McDermott P (2004) Ionizing radiation attracts soil fungi. Mycol Res 108:1089–1096
Acknowledgments
E. Dadachova is supported by the National Institute of Allergy and Infectious Disease (NIAID) grant AI60507; A. Casadevall – by NIAID grants AI033142 and AI033774.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer
About this entry
Cite this entry
Dadachova, E., Casadevall, A. (2011). Melanin and Resistance to Ionizing Radiation in Fungi. In: Horikoshi, K. (eds) Extremophiles Handbook. Springer, Tokyo. https://doi.org/10.1007/978-4-431-53898-1_55
Download citation
DOI: https://doi.org/10.1007/978-4-431-53898-1_55
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-53897-4
Online ISBN: 978-4-431-53898-1
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences